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Titolo:
An investigation of the serotonergic effects of fenfluramine, dexfenfluramine and dexnorfenfluramine using platelets as neuronal models
Autore:
Jagroop, IA; Mikhailidis, DP;
Indirizzi:
Univ London, Royal Free & Univ Coll Med Sch, Dept Mol Pathol & Clin Biochem, London NW3 2QG, England Univ London London England NW3 2QG Clin Biochem, London NW3 2QG, England
Titolo Testata:
PLATELETS
fascicolo: 3, volume: 11, anno: 2000,
pagine: 161 - 165
SICI:
0953-7104(200005)11:3<161:AIOTSE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY PULMONARY-HYPERTENSION; PERIPHERAL VASCULAR-DISEASE; CARCINOID HEART-DISEASE; SHAPE CHANGE; SMOOTH-MUSCLE; WHOLE-BLOOD; AGGREGATION; ACTIVATION; APPETITE; HEPARIN;
Keywords:
platelets; neurones; dexfenfluramine; fenfluramine; obesity; serotonin; platelet shape change;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Mikhailidis, DP Univ London, Royal Free & Univ Coll Med Sch, Dept Mol Pathol & Clin Biochem, Royal Free Campus, London NW3 2QG, England Univ London Royal Free Campus London England NW3 2QG land
Citazione:
I.A. Jagroop e D.P. Mikhailidis, "An investigation of the serotonergic effects of fenfluramine, dexfenfluramine and dexnorfenfluramine using platelets as neuronal models", PLATELETS, 11(3), 2000, pp. 161-165

Abstract

The appetite-suppressant, fenfluramine (d,l-F) has been used for several decades to treat obesity. Dexfen-fluramine (d-F), the d-enantiomer of d,l-F,was approved in 1995 for long-term administration, Subsequently, these drugs were voluntarily withdrawn due to reports of adverse effects on heart valves, So far, the evidence regarding the serotonergic action of d,l-F and d-F has relied on animal-based experiments. We used human platelets as neuronal models to assess the serotonergic action of both d,l-F, d-F and the main metabolite of d-F d-norfennuramine (d-norF), This was evaluated using a sensitive method that assesses platelet shape change (PSC) as expressed by an increase in median platelet volume (MPV), Human platelets increased theirMPV in response to d-norF, This action was probably mediated via serotonin(subtype 2) receptors because a specific antagonist blocked it, This is the first demonstration, using human tissue, of the serotonergic action associated with the administration of d-F.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:09:18