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Titolo:
Characteristics and outcome of children with carbon monoxide poisoning with and without smoke exposure referred for hyperbaric oxygen therapy
Autore:
Chou, KJ; Fisher, JL; Silver, EJ;
Indirizzi:
Albert Einstein Coll Med, Jacobi Med Ctr, Div Pediat Emergency Med, Bronx,NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 gency Med, Bronx,NY 10467 USA
Titolo Testata:
PEDIATRIC EMERGENCY CARE
fascicolo: 3, volume: 16, anno: 2000,
pagine: 151 - 155
SICI:
0749-5161(200006)16:3<151:CAOOCW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN LIPID-PEROXIDATION; INTOXICATION; MECHANISM; SEQUELAE; TOXICITY; RAT;
Keywords:
carbon monoxide poisoning; smoke inhalation; hyperbaric oxygen therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Chou, KJ 1W20 Jacobi Med Ctr, Pelham Pkwy & Eastchester Rd, Bronx, NY 10461 USA 1W20 Jacobi Med Ctr Pelham Pkwy & Eastchester Rd Bronx NY USA 10461
Citazione:
K.J. Chou et al., "Characteristics and outcome of children with carbon monoxide poisoning with and without smoke exposure referred for hyperbaric oxygen therapy", PEDIAT EMER, 16(3), 2000, pp. 151-155

Abstract

Objectives: To describe the clinical characteristics and outcome of children with carbon monoxide (CO) poisoning with and without smoke exposure referred for hyperbaric oxygen therapy (HBOT), and to determine the associationbetween any of these characteristics and death. Setting: Regional hyperbaric referral center,Patients: The medical records of 150 children with CO poisoning (COP) who were heated with HBOT between August 92 and September 95 were reviewed,Measurements/Main Results: COP was defined as a history of probable exposure to CO, with either a carboxyhemoglobin level (COHb) >25, or COHb <25 with neurological, respiratory, or cardiac compromise. Major cutaneous burns were described as second degree burns over greater than 20% of the patient'stotal body surface area (TBSA), or third degree burns over greater than 10% of the patient's TBSA. Children extracted from a closed-space fire who had airway soot, singed facial hair/facial burns, or respiratory distress were defined as having smoke inhalation and carbon monoxide poisoning (CO/SI),CO/SI occurred in 40.1% of patients. Compared to children with COP alone, those with CO/SI were significantly more likely to have a depressed mental status upon arrival to an ED (76.3% vs 13.6%, P < 0.001), lower mean initial GCS (6.7 vs 14.7, P < 0.001), lower mean initial pH (7.2 vs 7.4, P < 0.001), respiratory arrest at the scene (68.5% vs 0%, P < 0.001), and cardiac arrest at the scene (25.9% vs 0%, P < 0.001), Children with CO/SI were significantly more likely to have a poor outcome (death) than children with COP alone (22.6% vs. 0%, P < 0.001), Comparing children with CO/SI who died versus survivors, there were significant differences in mean initial COHb (38.3 vs 24.3, P = 0.03), mean initial temperature upon arrival in an ED (94.9 degrees F vs 98.2 degrees F, P < 0.006), respiratory arrest at the scene (92% vs 59.6%, P = 0.04), and cardiac arrest at the scene (66.7% vs 13.5%, P < 0.001), Sixty percent of children died who had a combination of risk factors of smoke inhalation, low temperature, high COHb level, and respiratory and cardiac arrest in the field. Conclusions: These preliminary data suggest that children with COP alone who are treated with HBOT are at low risk for dying regardless of initial COHb level. Children with CO/SI have a significantly higher risk of dying than those children with COP alone. A combination of smoke inhalation, low temperature, high COHb level, respiratory arrest, and cardiac arrest is highlyassociated with death. Prospective studies are needed to confirm and further define these associations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:59:11