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Titolo:
Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease
Autore:
Perez-Navarro, E; Akerud, P; Marco, S; Canals, JM; Tolosa, E; Arenas, E; Alberch, J;
Indirizzi:
Univ Barcelona, Fac Med, IDIBAPS, Dept Biol Cellular & Anat Patol, E-08036Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 at Patol, E-08036Barcelona, Spain Karolinska Inst, Mol Neurobiol Lab, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 phys, S-17177 Stockholm, Sweden Univ Barcelona, Hosp Clin, IDIBAPS, Neurol Serv, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 ol Serv, E-08036 Barcelona, Spain
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 98, anno: 2000,
pagine: 89 - 96
SICI:
0306-4522(2000)98:1<89:NPSPNB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; MIDBRAIN DOPAMINERGIC-NEURONS; NEUROTROPHIC FACTOR FAMILY; C-RET PROTOONCOGENE; NERVE GROWTH-FACTOR; IN-VIVO; NEURODEGENERATIVE DISORDERS; NEUROCHEMICAL DEFICITS; CHOLINERGIC NEURONS; EXCITOTOXIC DAMAGE;
Keywords:
NTN; GDNF; quinolinate; striatal neurons; grafting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Alberch, J Univ Barcelona, Fac Med, IDIBAPS, Dept Biol Cellular & Anat Patol, Casanova 143, E-08036 Barcelona, Spain Univ Barcelona Casanova 143 Barcelona Spain E-08036 ona, Spain
Citazione:
E. Perez-Navarro et al., "Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease", NEUROSCIENC, 98(1), 2000, pp. 89-96

Abstract

Glial cell line-derived neurotrophic Factor and neurturin are neurotrophicfactors expressed in the striatum during development and in the adult rat. Both molecules act as target-derived neurotrophic factors for nigrostriatal dopaminergic neurons. While glial cell line-derived neurotrophic factor has also been described to have local trophic effects on striatal neurons, the effects of neurturin in the striatum have not yet been described. Here we examine whether neurturin protects striatal projection neurons (calbindin-positive) and interneurons (parvalbumin- or choline acetyltransferase-positive) in an animal model of Huntington's disease. A fibroblast cell line engineered to over-express neurturin was grafted into adult rat striatum 24 hbefore quinolinate injection. In animals grafted with a control cell line,intrastriatal quinolinate injection reduced the number of calbindin-, parvalbumin- and choline acetyltransferase positive neurons, seven days post-lesion. Intrastriatal grafting of neurturin-secreting cells protected striatal projection neurons, but not interneurons, from quinolinate excitotoxicity. This effect was much more robust than that reported previously for a glial cell line-derived neurotrophic factor-secreting cell line on striatal calbindin-positive neurons. However, intrastriatal grafting of glial cell line-derived neurotrophic factor- but not neurturin-secreting cells prevented the decrease in choline acetyltransferase activity induced by quinolinate injection. Taken together, our results show that neurturin- and glial cell line-derived neurotrophic factor-secreting cell lines have clearly differential effects on striatal neurons. Grafting of the neurturin-secreting cell line showed a more specific and efficient trophic effect on striatal projection neurons, the neuronal population most affected in Huntington's disease. Therefore, our results suggest that neurturin is a good candidate for the treatmentof this neurodegenerative disorder. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 02:38:59