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Titolo:
Nerve growth factor but not neurotrophin-3 is synthesized by hippocampal gabaergic neurons that project to the medial septum
Autore:
Acsady, L; Pascual, M; Rocamora, N; Soriano, E; Freund, TF;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary Univ Barcelona, Fac Biol, Dept Anim & Plant Cell Biol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 ll Biol, E-08028 Barcelona, Spain ICO, Mol Biol Lab, Barcelona 08907, Spain ICO Barcelona Spain 08907ICO, Mol Biol Lab, Barcelona 08907, Spain
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 98, anno: 2000,
pagine: 23 - 31
SICI:
0306-4522(2000)98:1<23:NGFBNN>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY SYNAPTIC TRANSMISSION; RETROGRADE AXONAL-TRANSPORT; RAT HIPPOCAMPUS; ANTEROGRADE TRANSPORT; MESSENGER-RNAS; CELLULAR-LOCALIZATION; POSTSYNAPTIC TARGETS; PYRAMIDAL CELLS; BASAL FOREBRAIN; DIAGONAL BAND;
Keywords:
neurotrophins; interneurons; somatostatin; anterograde; retrograde; transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Freund, TF Hungarian Acad Sci, Inst Expt Med, POB 67, H-1450 Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 est, Hungary
Citazione:
L. Acsady et al., "Nerve growth factor but not neurotrophin-3 is synthesized by hippocampal gabaergic neurons that project to the medial septum", NEUROSCIENC, 98(1), 2000, pp. 23-31

Abstract

Conventional uptake of neurotrophins takes place at axon terminals via specific receptors, and is followed by retrograde transport. Recent studies demonstrated that, with the exception of nerve growth factor, other neurotrophins may be delivered anterogradely to the region containing the receptor expressing neurons. In this study we used a triple labeling method that combines retrograde tract tracing, in situ hybridization and immunocytochemistry to examine whether non-principal cells projecting from the hippocampus tothe septum synthesize nerve growth factor. Our results show that, on average, 59% of the horseradish peroxidase-labeled hippocamposeptal nonpyramidalneurons also display nerve growth factor messenger RNA hybridization signal. The ratio was slightly higher in the CAI stratum oriens and the hilus ofthe dentate gyrus (64 and 62%, respectively) compared to stratum oriens ofthe CA3 region (58%), In addition, we demonstrated that many nerve growth factor-positive septally projecting neurons also contain the calcium-binding protein calbindin D-28K, whereas nerve growth factor-negative projecting cells mostly lack this neurochemical marker. In contrast to nerve growth factor, neurotrophin-3 has never been found in hippocamposeptal cells. Hippocamposeptal GABAergic cells are reciprocally connected with the medial septum, thus they are in a key position to regulate nerve growth factor release as a function of the activity level in the septohippocampal system. Furthermore, our results raise the intriguing possibility that nerve growthfactor may be transported also in an anterograde manner. Regardless of thedirection of transport, the presence of nerve growth factor in hippocamposeptal cells suggests that long distance fast synaptic mechanisms and slow neurotrophin action are coupled in these neurons. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 04/12/20 alle ore 09:41:06