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Titolo:
Odors regulate Arc expression in neuronal ensembles engaged in odor processing
Autore:
Guthrie, K; Rayhanabad, J; Kuhl, D; Gall, C;
Indirizzi:
Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 t & Neurobiol, Irvine, CA 92697 USA Univ Hamburg, Ctr Mol Neurobiol ZMNH, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 biol ZMNH, D-20246 Hamburg, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 11, anno: 2000,
pagine: 1809 - 1813
SICI:
0959-4965(20000626)11:9<1809:ORAEIN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RAT OLFACTORY-BULB; FOS MESSENGER-RNA; SYNAPTIC ACTIVATION; ADULT MICE; PLASTICITY; DENDRITES; PROTEIN; SYSTEM; LOCALIZATION;
Keywords:
gene regulation; immediate early gene; odor mapping; olfactory bulb; olfactory system; sensory stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Guthrie, K Univ Calif Irvine, Dept Anat & Neurobiol, 3119 GNRF, Irvine, CA92697 USA Univ Calif Irvine 3119 GNRF Irvine CA USA 92697 e, CA 92697 USA
Citazione:
K. Guthrie et al., "Odors regulate Arc expression in neuronal ensembles engaged in odor processing", NEUROREPORT, 11(9), 2000, pp. 1809-1813

Abstract

Synaptic activity is critical to developmental and plastic processes that produce long-term changes in neuronal connectivity and function. Genes expressed by neurons in an activity-dependent fashion are of particular interest since the proteins they encode may mediate neuronal plasticity. One such gene encodes the activity-regulated cytoskeleton-associated protein, Are. The present study evaluated the effects of odor stimulation on Are expression in rat olfactory bulb. Are mRNA was rapidly increased in functionally linked cohorts of neurons topographically activated by odor stimuli. These included neurons surrounding individual glomeruli, mitral cells and transynaptically activated granule cells. Dendritic Are immunoreactivity was also increased in odor-activated glomeruli. Our results suggest that odor regulation of Are expression may contribute to activity-dependent structural changesassociated with olfactory experience. NeuroReport 11:1809-1813 (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 03/07/20 alle ore 16:41:28