Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The long-term effects of maternal deprivation depend on the genetic background
Autore:
Ellenbroek, BA; Cools, AR;
Indirizzi:
Dept Psychoneuropharmacol, NL-6500 HB Nijmegen, Netherlands Dept Psychoneuropharmacol Nijmegen Netherlands NL-6500 HB n, Netherlands
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 23, anno: 2000,
pagine: 99 - 106
SICI:
0893-133X(200007)23:1<99:TLEOMD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; STARTLE AMPLITUDE; ACOUSTIC STARTLE; RATS; SCHIZOPHRENIA; LEWIS; DOPAMINE; SYSTEM; FISCHER-344; APOMORPHINE;
Keywords:
animal models; apomorphine; maternal deprivation; prepulse inhibition; rat strains; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ellenbroek, BA Dept Psychoneuropharmacol, POB 9101, NL-6500 HB Nijmegen, Netherlands Dept Psychoneuropharmacol POB 9101 Nijmegen Netherlands NL-6500HB
Citazione:
B.A. Ellenbroek e A.R. Cools, "The long-term effects of maternal deprivation depend on the genetic background", NEUROPSYCH, 23(1), 2000, pp. 99-106

Abstract

The neurodevelopmental hypothesis of schizophrenia has led to a series of new animal models in which the long term consequences of early manipulations are investigated. We have recently shown that a single 24-hr period of maternal deprivation (at postnatal day (pnd) 9) increases apomorphine susceptibility and decreases prepulse inhibition in Wistar rats, viz. phenomena also seen in schizophrenic patients. In the present paper, we investigated whether the effects of maternal deprivation were dependent on a specific genetic background, by using different rat strains (Fischer 344 and Lewis) thatdiffer in the Hypothalamus-Pituitary-Adrenal axis and in dopaminergic sensitivity. The data show that in Wistar rats, basal startle amplitude was notaffected by maternal deprivation, but prepulse inhibition was reduced, andapomorphine susceptibility enhanced. In Fischer 344 rats on the other hand, neither basal startle amplitude, nor prepulse inhibition were affected, but apomorphine susceptibility was reduced. In Lewis rats, maternal deprivation significantly reduced basal startle amplitude, but did not affect prepulse inhibition or apomorphine susceptibility. The differential response to maternal deprivation can best be explained by differences in baseline dopamine sensitivity between the rat strains. Since a reduced prepulse inhibition and an enhanced susceptibility to apomorphine is also seen in schizophrenic patients, the data indicate that maternally deprived Wistar rats may represent an interesting developmental model for (aspects of) schizophrenia. [Neuropsychopharmacology 23:99-106, 2000] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:40:56