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Titolo:
Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: A longitudinal study in patients treated with amitriptyline or paroxetine
Autore:
Hinze-Selch, D; Schuld, A; Kraus, T; Kuhn, M; Uhr, M; Haack, M; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 1, volume: 23, anno: 2000,
pagine: 13 - 19
SICI:
0893-133X(200007)23:1<13:EOAOWA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; TRANSFERRIN RECEPTOR; MAJOR DEPRESSION; BODY-WEIGHT; INTERLEUKIN-2; CLOZAPINE; SCHIZOPHRENIA; CYTOKINE; SEROTONIN; INCREASE;
Keywords:
soluble TNF receptors; leptin; body mass index; tricyclic antidepressants; serotonin reuptake inhibitor; drug-free;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Pollmacher, T Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
D. Hinze-Selch et al., "Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: A longitudinal study in patients treated with amitriptyline or paroxetine", NEUROPSYCH, 23(1), 2000, pp. 13-19

Abstract

Leptin, tumor necrosis factor-alpha (TNF-alpha), and soluble TNF receptorsare involved in weight regulation. Antipsychotic agents, such as clozapine, induce weight gain and increase circulating levels of these cytokines. Toassess whether obesity-inducing antidepressants have a similar effect, toemeasured plasma cytokine levels in depressive inpatients during the first six weeks of treatment with tricyclic agents (amitriptyline or nortriptyline, n = 12), with paroxetine (n = 10), or without medication (n = 14). Therewas an increase in the body mass index at week 6 of treatment with the tricyclics, which was preceded by a significant increase in soluble TNF receptor p75 plasma levels. Circulating levels of leptin were not affected. Paroxetine and drug-free treatment did not affect any of these parameters. We conclude that weight gain induced by psychotropic agents may occur without increased circulating levels of leptin. However, activation of the TNF-alpha system might be an early and sensitive marker of ensuing weight gain. [Neuropsychopharmacology 23:13-19, 2000] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:29:19