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Titolo:
Reduction of handwriting area and D-2 dopamine receptor occupancy in therapy with typical and atypical neuroleptic drugs
Autore:
Kunstler, U; Hohdorf, K; Regenthal, R; Seese, A; Gertz, HJ;
Indirizzi:
Univ Leipzig, Psychiat Klin & Poliklin, Leipzig, Germany Univ Leipzig Leipzig Germany Psychiat Klin & Poliklin, Leipzig, Germany Univ Leipzig, Nukl Med Klin & Poliklin, D-7010 Leipzig, Germany Univ Leipzig Leipzig Germany D-7010 & Poliklin, D-7010 Leipzig, Germany Inst Klin Pharmakol, Leipzig, Germany Inst Klin Pharmakol Leipzig Germany st Klin Pharmakol, Leipzig, Germany
Titolo Testata:
NERVENARZT
fascicolo: 5, volume: 71, anno: 2000,
pagine: 373 - 379
SICI:
0028-2804(200005)71:5<373:ROHAAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
GER
Soggetto:
SCHIZOPHRENIC-PATIENTS; RATING-SCALE; D2 RECEPTORS; CLOZAPINE; PET; TOMOGRAPHY; INVITRO;
Keywords:
reduction of handwriting area; D-2 dopamine receptor occupancy; typical and atypical neuroleptic drugs extrapyramidal motor symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kunstler, U Univ Bern, Psychiat Dienste Bern, Murtenstr 21, CH-3000 Bern 10, Switzerland Univ Bern Murtenstr 21 Bern Switzerland 10 rn 10, Switzerland
Citazione:
U. Kunstler et al., "Reduction of handwriting area and D-2 dopamine receptor occupancy in therapy with typical and atypical neuroleptic drugs", NERVENARZT, 71(5), 2000, pp. 373-379

Abstract

Beside the typical extrapyramidal motor symptoms such as rigidity, tremor,and dyskinesia, a reduction in handwriting area may occur under neuroleptic therapy. To date,the nature of the relationship between a reduction in handwriting area and striatal D-2 dopamine receptor occupancy has remained unclear, and it is not known whether such a reduction also occurs under treatment with atypical neuroleptic drugs. In 23 schizophrenic patients treated with haloperidol, haloperidol decanoate, risperidone, and clozapine, the handwriting area was examined using a planimetric computer program. (123)l-iodobenzamide (IBZM) single photon emission tomography (SPET) was used to measure the D-2 dopamine rec statistically significant correlation was found between a reduction in handwriting area and D-2 dopamine receptor occupancy (r = 0.86; P < 0.0001). The curve derived from the plotted data resulted ina hyperbolic function. The regression was present regardless of whether the patients were treated with typical or atypical neuroleptic drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:44:36