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Titolo:
Glucocorticoid modulation of dopamine mediated effects on hypothalamic atrial natriuretic factor neurons
Autore:
Lee, D; Huang, W; Wang, L; Copolov, D; Lim, AT;
Indirizzi:
Mental Hlth Res Inst Victoria, Div Mol Schizophrenia, Cell Biol Lab, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria Parkville Vic Australia 3052 052, Australia Monash Univ, Dept Psychol Med, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 Med, Clayton, Vic 3168, Australia
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 3, volume: 5, anno: 2000,
pagine: 332 - 336
SICI:
1359-4184(200005)5:3<332:GMODME>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; PEPTIDE ANP SECRETION; SCHIZOPHRENIA; RECEPTORS; CULTURE; ADRENOCEPTOR; MACROPHAGES; PLASTICITY; D-2;
Keywords:
dopamine receptor subtypes; atrial natriuretic factor producing neurons; glucocorticoid; primary neuron cultures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Lim, AT Mental Hlth Res Inst Victoria, Div Mol Schizophrenia, Cell Biol Lab, 155 Oak St, Parkville, Vic 3052, Australia Mental Hlth Res Inst Victoria155 Oak St Parkville Vic Australia 3052
Citazione:
D. Lee et al., "Glucocorticoid modulation of dopamine mediated effects on hypothalamic atrial natriuretic factor neurons", MOL PSYCHI, 5(3), 2000, pp. 332-336

Abstract

Dopamine (DA) plays an important role in cognition, neuroendocrine functions and psychosis.(1,2) Whilst stress adversely affects some of these functions, its neurobiological basis remains unclear.(3) In the rat hypothalamus,a concurrent activation of D-5, and D-2, receptors by dopamine produces a biphasic effect on the function of atrial natriuretic factor (ANF) neurons.(4) Whereas low doses (10(-8) and 10(-7) NI) of DA suppress the release andpro-ANF mRNA expression, high doses (10(-6) and 10(-5) M) of the amine produce an opposite effect through the interaction of D-5 and D-2 receptors, We report here that the augmenting effect of DA on the hypothalamic neurons is inhibited by a synthetic glucocorticoid, dexamethasone (DM), in both time-dependent and dose-related manner with an EC50 of 0.1 nM, Furthermore, the inhibition is blocked by 100 nM of RU38486 (P < 0,01), a glucocorticoid receptor antagonist, but not by an equivalent dose of RU28318, a mineralocorticoid receptor antagonist. In contrast, DM failed to modulate low doses (10-8 to 10-7 M) of DA-induced suppression of ir-ANF release and pro-ANF mRNAexpression that was mediated primarily through D-2, receptors, We concludethat glucocorticoids markedly alter DA-induced biphasic effects by down-regulating D-5, but not D-2, receptor-mediated neurobiological events. Hence,in severe stress, high levels of circulating glucocorticoids may render dopamine to act as a potent suppressor of neurons that possess both D-5 and D-2 receptors, The possibility that this novel mechanism of stress hormone or glucocorticoids may, in part, undermine DA-mediated neurophysiology in critical regions of the brain, which links to psychosis now needs to be considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:55:36