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Titolo:
TaqIB allele polymorphism of the dopamine receptor D2 gene in patients with endogenous psychoses
Autore:
Aksenova, MG; Ab, OV; Golimbet, VE; Abramova, LI; Orlova, VA; Kaleda, VG; Oleichik, IV; Nosikov, VV;
Indirizzi:
State Res Ctr GosNIIgenetika, Moscow 113545, Russia State Res Ctr GosNIIgenetika Moscow Russia 113545 Moscow 113545, Russia Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 113152, Russia Russian Acad Med Sci Moscow Russia 113152 Res Ctr, Moscow 113152, Russia
Titolo Testata:
MOLECULAR BIOLOGY
fascicolo: 3, volume: 34, anno: 2000,
pagine: 328 - 330
SICI:
0026-8933(200005/06)34:3<328:TAPOTD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NO ASSOCIATION; AFFECTIVE-DISORDERS; SUBSTANCE-ABUSE; DRD2; D-2; SCHIZOPHRENIA; LINKAGE; HAPLOTYPES; ALCOHOLISM; VARIANTS;
Keywords:
dopamine receptor D2; TaqIB RFLP; allele polymorphism; endogenous psychoses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Aksenova, MG State Res Ctr GosNIIgenetika, Moscow 113545, Russia State ResCtr GosNIIgenetika Moscow Russia 113545 5, Russia
Citazione:
M.G. Aksenova et al., "TaqIB allele polymorphism of the dopamine receptor D2 gene in patients with endogenous psychoses", MOL BIOL, 34(3), 2000, pp. 328-330

Abstract

The genotype at the TaqIB locus of the dopamine receptor D2 (DRD2) gene was established by PCR in 113 healthy donors and 340 patients with endogenouspsychoses. The allele and genotype frequencies in patients with affective psychoses significantly differed from those in controls and in patients with schizophrenia. The proportion of B2/B2 homozygotes decreased with increasing contribution of the affective component to the clinical manifestation of schizo-affective and affective disorders. The TaqIB polymorphism was assumed to play a role in mood aberrations in patients with mental disorders.

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Documento generato il 26/01/20 alle ore 15:59:15