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Titolo:
Analogous standard motifs in myelin basic protein and in MARCKS
Autore:
Harauz, G; Ishiyama, N; Bates, I;
Indirizzi:
Univ Guelph, Dept Mol Biol & Genet, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 & Genet, Guelph, ON N1G 2W1, Canada Univ Guelph, Biophys Interdepartmental Grp, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 ntal Grp, Guelph, ON N1G 2W1, Canada
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 209, anno: 2000,
pagine: 155 - 163
SICI:
0300-8177(200006)209:1-2<155:ASMIMB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-KINASE SUBSTRATE; 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE; OLIGODENDROGLIAL MEMBRANE SHEETS; ACIDIC LIPID VESICLES; GTP-BINDING PROTEINS; BOVINE BRAIN; MULTIPLE-SCLEROSIS; SECONDARY STRUCTURE; PHOSPHOLIPASE-C; POSTTRANSLATIONAL MODIFICATIONS;
Keywords:
calmodulin; myelin basic protein; MBP; myristoylated alanine-rich C-kinase substrate; MARCKS; myelination; signal transduction;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Harauz, G Univ Guelph, Dept Mol Biol & Genet, Guelph, ON N1G 2W1, Canada Univ Guelph Guelph ON Canada N1G 2W1 Guelph, ON N1G 2W1, Canada
Citazione:
G. Harauz et al., "Analogous standard motifs in myelin basic protein and in MARCKS", MOL C BIOCH, 209(1-2), 2000, pp. 155-163

Abstract

Myelin basic protein (MBP) and myristoylated alanine-rich C-kinase substrate (MARCKS) are similar in terms of having extended conformations regulatedby their environment (i.e., solubilised or lipid-associated), N-terminal modifications, a dual nature of interactions with lipids, binding to actin and Ca2+-calmodulin, and being substrates for different kinds of protein kinases. The further sequence similarities of segments of MBP with lipid effector regions of MARCKS, and numerous reports in the literature, support the thesis that some developmental isoform of MBP functions in signal transduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:17:34