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Titolo:
Microvascular perfusion and transport in the diabetic heart
Autore:
McDonagh, PF; Hokama, JY;
Indirizzi:
Univ Arizona, Hlth Sci Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 zona, Hlth Sci Ctr, Tucson, AZ 85724 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Expt Therapeut & Reperfus Injury, Boston, MA USA Harvard Univ Boston MA USA t Therapeut & Reperfus Injury, Boston, MA USA
Titolo Testata:
MICROCIRCULATION
fascicolo: 3, volume: 7, anno: 2000,
pagine: 163 - 181
SICI:
1073-9688(200006)7:3<163:MPATIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPAIRED GRANULOCYTE-ADHERENCE; MYOCARDIAL REPERFUSION INJURY; CORONARY FLOW RESERVE; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; POLYMORPHONUCLEAR LEUKOCYTES; VASCULAR-PERMEABILITY; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; SKELETAL-MUSCLE;
Keywords:
coronary microcirculation; diabetes; heart; coronary blood flow; nitric oxide; ischemia-reperfusion injury; oxidative stress; inflammatory response;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: McDonagh, PF Univ Arizona, Hlth Sci Ctr, POB 245071, Tucson, AZ 85724 USA Univ Arizona POB 245071 Tucson AZ USA 85724 son, AZ 85724 USA
Citazione:
P.F. McDonagh e J.Y. Hokama, "Microvascular perfusion and transport in the diabetic heart", MICROCIRCUL, 7(3), 2000, pp. 163-181

Abstract

Diabetes is a chronic disease of metabolic dysfunction that is increasing worldwide. The hyperglycemia associated with diabetes causes significant protein alterations and an oxidative su ess. In the heart, all cell types areaffected by diabetes; the myocyte, the vasculature and the blood cells. Four out of five diabetics die from ischemic heart disease and stroke, suggesting that the diabetic is quite vulnerable to ischemic injury. It is important to understand the pathophysiologic changes that occur in the diabetic heart in order to develop thoughtful treatments to limit this serious complication. This review focuses on the anatomical and functional alterations that occur in the diabetic circulation of the heart, with emphasis on the coronary microcirculation. Coronary microvascular dysfunction combined with blood cellular alterations are presented to explain the amplified oxidative stress that occurs in the diabetic heart under ischemic conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 07:24:30