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Titolo:
The microcirculation and inflammation: Site of action for glucocorticoids
Autore:
Perretti, M; Ahluwalia, A;
Indirizzi:
William Harvey Res Inst, Dept Biochem Pharmacol, London EC1M 6BQ, England William Harvey Res Inst London England EC1M 6BQ London EC1M 6BQ, England Univ Coll London, Rayne Inst, Ctr Clin Pharmacol, London, England Univ Coll London London England st, Ctr Clin Pharmacol, London, England
Titolo Testata:
MICROCIRCULATION
fascicolo: 3, volume: 7, anno: 2000,
pagine: 147 - 161
SICI:
1073-9688(200006)7:3<147:TMAISO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; ENDOTHELIAL-CELL-ADHESION; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; BLOOD MONONUCLEAR LEUKOCYTES; VASCULAR SMOOTH-MUSCLE; LATE SEPTIC SHOCK; ANNEXIN-I; UP-REGULATION; L-SELECTIN;
Keywords:
steroids; dexamethasone; oedema; blood flow; leukocyte migration; annexin 1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Perretti, M William Harvey Res Inst, Dept Biochem Pharmacol, Charterhouse Sq, London EC1M 6BQ, England William Harvey Res Inst Charterhouse Sq London England EC1M 6BQ
Citazione:
M. Perretti e A. Ahluwalia, "The microcirculation and inflammation: Site of action for glucocorticoids", MICROCIRCUL, 7(3), 2000, pp. 147-161

Abstract

The glucocorticoid hormones and their synthetic derivatives are potent suppressors of inflammatory and allergic pathologies. Their widespread efficacy is the result of multiple modes of action occuring predominantly at the level of the microcirculation. Indeed the glucocorticoids interfere with thefunction of all of the cellular components of the microcirculation associated with an inflammatory response. These agents inhibit vasodilatation of the arteriolar and capillary beds, therefore preventing the increase in blood flow that characterizes the initial stages of the inflammatory response. They also prevent increases in vascular permeability in the capillary and post-capillary venule, thereby reducing exudate formation. Finally, the glucocorticoids potently suppress leukocyte emigration across post-capillary venules. However, this promiscuity of the glucocorticods to act at multiple sites also endows this class of drugs with major side effects associated with chronic treatment. We propose that one way to progress forward is to understand better the effects of glucocorticoids within the microcirculation. This may aid identification of specific molecular sites of action and therefore the development of novel glucocorticoid molecules with fewer side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:11:48