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Titolo:
Effect of muscarinic receptor agonists on animal models of psychosis
Autore:
Karan, RS; Ravishankar, P; Pandhi, P;
Indirizzi:
Postgrad Inst Med Educ & Res, Dept Pharmacol, Chandigarh 160012, India Postgrad Inst Med Educ & Res Chandigarh India 160012 igarh 160012, India
Titolo Testata:
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
fascicolo: 3, volume: 22, anno: 2000,
pagine: 169 - 172
SICI:
0379-0355(200004)22:3<169:EOMRAO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINERGIC HYPERACTIVITY; SCHIZOPHRENIA; ACTIVATION; SYMPTOMS; NEURONS; PHYSOSTIGMINE; DISEASE; RAT;
Keywords:
physostigmine; pilocarpine; catalepsy; stereotypy; conditioned avoidance response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Pandhi, P Postgrad Inst Med Educ & Res, Dept Pharmacol, Chandigarh 160012,India Postgrad Inst Med Educ & Res Chandigarh India 160012 12, India
Citazione:
R.S. Karan et al., "Effect of muscarinic receptor agonists on animal models of psychosis", METH FIND E, 22(3), 2000, pp. 169-172

Abstract

The purpose of this study was to determine the effects of muscarinic receptor agonists on models of psychosis in rats. A battery of three tests, catalepsy (haloperidol-induced) augmentation, amphetamine-induced stereotypy antagonism and conditioned avoidance response were used. Both muscarinic receptor agonists physostigmine and pilocarpine produced similar results. They dose-dependently augmented the haloperidol-induced catalepsy, inhibited amphetamine-induced stereotypy behavior and inhibited the conditioned avoidance response. Results demonstrate that muscarinic receptor agonists have actions similar to those of dopamine receptor antipsychotic drugs in animal models, suggesting that muscarinic receptor agonists may be used as adjuvant drugs in the treatment of psychosis. (C) 2000 Prous Science. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:38:09