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Titolo:
Energy metabolism in graded perinatal asphyxia of the rat
Autore:
Seidl, R; Stockler-Ipsiroglu, S; Rolinski, B; Kohlhauser, C; Herkner, KR; Lubec, B; Lubec, G;
Indirizzi:
Univ Vienna, Dept Pediat, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Pediat, A-1090 Vienna, Austria Univ Munich, Childrens Hosp, Dept Clin Chem, Munich, Germany Univ Munich Munich Germany ldrens Hosp, Dept Clin Chem, Munich, Germany
Titolo Testata:
LIFE SCIENCES
fascicolo: 4, volume: 67, anno: 2000,
pagine: 421 - 435
SICI:
0024-3205(20000616)67:4<421:EMIGPA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; ELECTRON-TRANSPORT CHAIN; ISCHEMIC BRAIN-DAMAGE; PROTEIN-KINASE-C; MEASURED IN-VIVO; IMMATURE RAT; POSTNATAL-DEVELOPMENT; BETA-HYDROXYBUTYRATE; NEURONAL DEATH; LACTATE;
Keywords:
asphyxia; ATP; phosphocreatine; lactate; brain; heart; kidney;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lubec, G Univ Vienna, Dept Pediat, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 stria
Citazione:
R. Seidl et al., "Energy metabolism in graded perinatal asphyxia of the rat", LIFE SCI, 67(4), 2000, pp. 421-435

Abstract

Although information on energy metabolism during hypoxemic-ischemic statesis abundant, data on perinatal asphyxia (PA) are limited. As results from hypoxia-ischemia cannot be directly extrapolated to PA, a clinical entity characterized by acidosis, hypoxemia and hypercapnia, we decided to use a rat model of graded PA during delivery. Cesarean section was performed at the21st day of gestation and the pups, still in the uterus horns, were asphyxiated from 0 to 20 minutes. In this model survival decreases with the length of asphyxia. Early changes of energy-rich phosphates in brain, heart and kidney were determined by HPLC. ATP and phosphocreatine gradually decreasedwith the length of asphyxia, with highest ATP depletion rate occurring in the kidney. ATP: brain 1.39+/-0.71 (0 min) to 0.06 mu M/g wwt (20 min); heart 4.73+/-0.34 (0 min) to 1.08+/-0.47 (20 min); kidney 1.62+/-0.11 (0 min) to 0.02+/-0.02 (20 min). Phosphocreatine: brain 1.65+/-0.68 (0 min) to 0.5+/-0.45 mu M/g (20 min); heart 6.98+/-0.38 (0 min) to 6.17+/-1.07 (20 min); kidney 8.23+/-0.86 (0 min) to 3.76+/-0.54 (20 min). We present data on energy derangement in a rat model of PA, closely resembling the clinical situation, showing that energy depletion precedes cell damage and death. (C) 2000Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:55:49