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Titolo:
Oxidative injury is present in Purkinje cells in patients with olivopontocerebellar atrophy
Autore:
Yamashita, T; Ando, Y; Obayashi, K; Terazaki, H; Sakashita, N; Uchida, K; Ohama, E; Ando, M; Uchino, M;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 rnal Med 1, Kumamoto 8600811, Japan Kumamoto Univ, Sch Med, Dept Neurol, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 ept Neurol, Kumamoto 8600811, Japan Kumamoto Univ, Sch Med, Dept Pathol 2, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 t Pathol 2, Kumamoto 8600811, Japan Nagoya Univ, Sch Agr, Lab Food & Biodynam, Chikusa Ku, Nagoya, Aichi 4640814, Japan Nagoya Univ Nagoya Aichi Japan 4640814 a Ku, Nagoya, Aichi 4640814, Japan Tottori Univ, Fac Med, Dept Neurol Pathol, Yonago, Tottori 6830826, Japan Tottori Univ Yonago Tottori Japan 6830826 Yonago, Tottori 6830826, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 175, anno: 2000,
pagine: 107 - 110
SICI:
0022-510X(20000415)175:2<107:OIIPIP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
4-HYDROXYNONENAL PROTEIN; PEROXIDATION;
Keywords:
oxidative stress; cerebellum; degeneration; SCD; hydroxynonenal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ando, Y Kumamoto Univ, Sch Med, Dept Internal Med 1, 1-1-1 Honjo, Kumamoto8600811, Japan Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8600811 o 8600811, Japan
Citazione:
T. Yamashita et al., "Oxidative injury is present in Purkinje cells in patients with olivopontocerebellar atrophy", J NEUR SCI, 175(2), 2000, pp. 107-110

Abstract

To verify the presence of lipid peroxidation products in spinocerebellar degeneration (SCD), the cerebella from eight patients with olivopontocerebellar atrophy (OPCA) and six non-OPCA patients were immunohistochemically investigated with 4-hydroxy-2-nonenal (HNE) antibody. On average, 84.6% of Purkinje cells were positively or strongly positively immunostained in OPCA patients while only 15.5% were positive in non-OPCA patients. Other cells in the molecular and granular layers showed no obvious immunoreactivity. Thesedata suggest that a lipid peroxidation product is present in Purkinje cells of OPCA patients and that oxidative stress may play an important role in the degeneration process of SCD. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:31:49