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Titolo:
CARDIOVASCULAR AFFERENT INPUTS TO VENTRAL TEGMENTAL AREA
Autore:
KIROUAC GJ; CIRIELLO J;
Indirizzi:
UNIV WESTERN ONTARIO,HLTH SCI CTR,DEPT PHYSIOL LONDON ON N6A 5C1 CANADA UNIV WESTERN ONTARIO,HLTH SCI CTR,DEPT PHYSIOL LONDON ON N6A 5C1 CANADA
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 6, volume: 41, anno: 1997,
pagine: 1998 - 2003
SICI:
0363-6119(1997)41:6<1998:CAITVT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINOAORTIC-DENERVATED RATS; STRIATAL DOPAMINE RELEASE; HORSERADISH-PEROXIDASE; RETICULAR-FORMATION; SOLITARY TRACT; PROJECTIONS; NUCLEUS; STIMULATION; NEURONS; SYSTEM;
Keywords:
NUCLEUS OF THE SOLITARY TRACT; NUCLEUS ACCUMBENS; CARDIOVASCULAR REFLEX PATHWAYS; DOPAMINE; ARTERIAL BARORECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Kirouac e J. Ciriello, "CARDIOVASCULAR AFFERENT INPUTS TO VENTRAL TEGMENTAL AREA", American journal of physiology. Regulatory, integrative and comparative physiology, 41(6), 1997, pp. 1998-2003

Abstract

Extracellular single-unit recording experiments were done in alpha-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of selective activation of arterial baroreceptors and stimulation of cardiovascular depressor sites in the nucleus ofthe solitary tract (NTS) on the discharge rate of neurons in the ventral tegmental area (VTA). Electrical stimulation of the aortic depressor nerve (ADN), which is known to carry aortic baroreceptor afferent fibers only, excited 12 of 21 (mean onset latency 42.4 +/- 8.8 ms) and inhibited 2 of 21 (mean onset latency 42.5 +/- 6.5 ms) single units inthe VTA. The discharge rate of VTA units was also altered during the reflex activation of arterial baroreceptors by the acute rise in arterial pressure (AP) to systemic injections of phenylephrine (10 mu g/kg iv): 12 of 44 units were excited and 15 of 44 were inhibited. Units that responded to either ADN stimulation or the reflex activation of thebaroreflex also responded to stimulation of depressor sites in the NTS. An additional 12 units that were found in barodenervated controls to be responsive to NTS stimulation were nonresponsive to selective activation of arterial baroreceptors. These data indicate that cardiovascular afferent inputs modulate the activity of neurons in the VTA and suggest that changes in systemic AP may exert an effect on the activityof neurons involved in mesolimbic and mesocortical function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 19:54:32