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Titolo:
Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents
Autore:
Strauss, RS; Barlow, SE; Dietz, WH;
Indirizzi:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Div Pediat Gastroenterol & Nutr, New Brunswick, NJ 08903 USA Univ Med & Dent New Jersey NewBrunswick NJ USA 08903 swick, NJ 08903 USA St Louis Univ, Sch Med, Cardinal Glennon Childrens Hosp, Div Pediat Gastroenterol & Hepatol, St Louis, MO 63104 USA St Louis Univ St Louis MO USA 63104 rol & Hepatol, St Louis, MO 63104 USA Ctr Dis Control, Ctr Chron Dis Prevent & Hlth Promot, Div Nutr & Phys Act,Atlanta, GA 30333 USA Ctr Dis Control Atlanta GA USA 30333 utr & Phys Act,Atlanta, GA 30333 USA
Titolo Testata:
JOURNAL OF PEDIATRICS
fascicolo: 6, volume: 136, anno: 2000,
pagine: 727 - 733
SICI:
0022-3476(200006)136:6<727:POASAV>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; FOLLOW-UP; NATURAL-HISTORY; CHILDREN; ALCOHOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Strauss, RS Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Div Pediat Gastroenterol & Nutr, 1 Robert Wood Johnson Pl, New Brunswick, NJ 08903 USA Univ Med & Dent New Jersey 1 Robert Wood Johnson Pl New Brunswick NJUSA 08903
Citazione:
R.S. Strauss et al., "Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents", J PEDIAT, 136(6), 2000, pp. 727-733

Abstract

Objectives: (1) To determine the prevalence of abnormal liver enzymes in overweight and obese adolescents and (2) to determine the relationship of alcohol ingestion and serum antioxidants to the presence of abnormal liver enzymes in overweight and obese adolescents. Methods: Serum alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase levels were measured in 2450 children between the ages of 12 and 18 years, enrolled in the National Health and Examination Surveys cycle III (NHANES III). Obesity was defined as a body mass index >95th percentile for age and sex. Overweight was defined as a body mass index >85th percentile forage and sex. Nutritional intake was assessed by 24-hour dietary recall andfood frequency questionnaires. Serum antioxidants were measured by high-pressure liquid chromatography. Results: Sixty percent of adolescents with elevated ALT levels were eitheroverweight or obese. Overall, 6% Of overweight adolescents had elevated ALT levels (odds ratio: 3.4 [95% CI: 3.5-12.8]). Ten percent of obese adolescents had elevated ALT levels (odds ratio: 6.7 [95% CI: 3.5-12.8]). In addition, approximately 1% of obese adolescents demonstrated ALT levels over twice normal. Approximately 50% of of obsese adolescents who reported modest alcohol ingestion (4 times per month or more) had elevated ALT levels (odds ratio: 10.8, 95% CI: 1.5-77). Other factors associated with elevated ALT levels in overweight and obese adolescents include increased age, elevated glycolated hemoglolin, elevated triglycerides, and decreased levels of serum antioxidants-vitamin E, beta-carotene, and vitamin C. Conclusion: Overweight and obesity are the most common findings in adolescents with elevated ALT levels. Even modest alcohol consumption may significantly increase the likelihood of obese adolescents developing obesity-related liver disease.

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Documento generato il 29/09/20 alle ore 23:34:08