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Titolo:
Stress perfusion/metabolism imaging: A pilot study for a potential new approach to the diagnosis of coronary disease in women
Autore:
Abramson, BL; Ruddy, TD; deKemp, RA; Laramee, LA; Marquis, JF; Beanlands, RSB;
Indirizzi:
St Michaels Hosp, Div Cardiol, Toronto, ON M5B 1W8, Canada St Michaels Hosp Toronto ON Canada M5B 1W8 l, Toronto, ON M5B 1W8, Canada Univ Ottawa, Inst Heart, Div Cardiol, Ottawa, ON, Canada Univ Ottawa Ottawa ON Canada Inst Heart, Div Cardiol, Ottawa, ON, Canada
Titolo Testata:
JOURNAL OF NUCLEAR CARDIOLOGY
fascicolo: 3, volume: 7, anno: 2000,
pagine: 205 - 212
SICI:
1071-3581(200005/06)7:3<205:SPIAPS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; ISCHEMIC HEART-DISEASE; ARTERY DISEASE; COMPUTED-TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; MYOCARDIAL-ISCHEMIA; N-13 AMMONIA; EXERCISE; TL-201; PERFUSION;
Keywords:
coronary artery disease; F-18 deoxyglucose; positron emission tomography; women;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Abramson, BL St Michaels Hosp, Div Cardiol, 30 Bond St,Rm 3-054,Victoria Wing, Toronto,ON M5B 1W8, Canada St Michaels Hosp 30 Bond St,Rm 3-054,Victoria Wing Toronto ON Canada M5B 1W8
Citazione:
B.L. Abramson et al., "Stress perfusion/metabolism imaging: A pilot study for a potential new approach to the diagnosis of coronary disease in women", J NUCL CARD, 7(3), 2000, pp. 205-212

Abstract

Background. The diagnosis of coronary artery disease (CAD) in women continues to be a challenge. F-18 deoxyglucose (FDG) positron emission tomography(PET) has been used for detection of myocardial ischemia at rest, Little has been reported about FDG stress imaging. The aim of this pilot study was to assess stress FDG PET imaging for defining CAD in a group of women referred for chest pain. Methods. Stress FDG imaging was performed in 19 women (mean age 59 +/- 10 years). All had abnormal stress testing before entering the study. FDG and 2-methoxy-2-methylpropyl isonitrile were injected at peak stress (treadmilln = 8, dipyridamole n = 11) followed by PET and single photon emission computed tomography image acquisitions. Myocardial ischemia was defined by regions that demonstrated both a defect on perfusion imaging and increased FDGuptake relative to uptake in normal perfusion zones. Defect/normal zone FDG ratios were also determined. Coronary angiography was performed on all patients. Results, Average, or mean, body mass index was high at 29.2 +/- 5 kg/m(2). Nine of 19 patients had significant CAD. Eight of 9 with CAD had FDG-defined ischemia, Nine of the 10 without CAD had negative FDG images (sensitivity 89%, specificity 90%). The average defect/normal zone FDG ratio was greater in patients with CAD than in those without (2.4 +/- 1.9 vs 0.9 +/- 0.4, P < .05). Conclusions, Regional FDG uptake in areas of perfusion defects,vith stressincreased in this group with CAD. These pilot data suggest that stress FDGPET may be diagnostically helpful in obese female patients. This novel approach may complement current methods of CAD detection in women and warrantsfurther study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:36:59