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Titolo:
Neurologic disease in injection drug users: therapeutic issues
Autore:
Royal, W;
Indirizzi:
Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 ch Med, Baltimore, MD 21287 USA
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
, volume: 6, anno: 2000, supplemento:, 1
pagine: S33 - S37
SICI:
1355-0284(200005)6:<S33:NDIIDU>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LIVER-MICROSOMES; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; CYTOCHROME-P450 3A4; HIV-1 INFECTION; AIDS; METHADONE; DEMENTIA; COCAINE; INVOLVEMENT; ZIDOVUDINE;
Keywords:
human immunodeficiency; methadone; cocaine; nervous system; antiretroviral therapy; injection drug use;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Royal, W Morehouse Sch Med, 7200 Westview Dr SW, Atlanta, GA 30310 USA Morehouse Sch Med 7200 Westview Dr SW Atlanta GA USA 30310 10 USA
Citazione:
W. Royal, "Neurologic disease in injection drug users: therapeutic issues", J NEUROVIRO, 6, 2000, pp. S33-S37

Abstract

Illicit drug use may cause nervous system impairment as a result of directand indirect effects on the integrity and function of nervous system tissue and, potentially, through immune effects. HIV-1 infection poses an additional risk of impairment, and this risk may be decreased as a result of antiretroviral drug treatment. Obviously, the goal of such therapy is to improve the potential clinical course of infection. However, interactions betweenantiretroviral drugs, abused drugs, and hepatic metabolic enzyme systems may result in impaired or more efficient drug clearance and, consequently, antiretroviral or substance abuse treatment failure. The clinical outcome ofthis interaction may potentially include drug-related neurotoxicity or neurologic disease induced by HIV infection. The actual impact of these interactions on the occurrence of neurologic impairment and disease are unknown at this time, and, therefore, require study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:28:25