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Titolo:
MRI correlates of cognitive dysfunction in multiple sclerosis patients
Autore:
Rovaris, M; Filippi, M;
Indirizzi:
Osped San Raffaele, Inst Sci, Dept Neurosci, Neuroimaging Res Unit, I-20132 Milan, Italy Osped San Raffaele Milan Italy I-20132 ng Res Unit, I-20132 Milan, Italy
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
, volume: 6, anno: 2000, supplemento:, 2
pagine: S172 - S175
SICI:
1355-0284(200005)6:<S172:MCOCDI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
APPEARING WHITE-MATTER; SPIN-ECHO; QUANTITATIVE ASSESSMENT; HYPOINTENSE LESIONS; AXONAL DAMAGE; PATHOLOGY; PATTERNS; ABNORMALITIES; DISABILITY; IMPAIRMENT;
Keywords:
multiple sclerosis; magnetic resonance imaging; cognitive functions; frontal lobe; magnetisation transfer imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Filippi, M Osped San Raffaele, Inst Sci, Dept Neurosci, Neuroimaging Res Unit, Via Olgettina 60, I-20132 Milan, Italy Osped San Raffaele Via Olgettina 60 Milan Italy I-20132 Italy
Citazione:
M. Rovaris e M. Filippi, "MRI correlates of cognitive dysfunction in multiple sclerosis patients", J NEUROVIRO, 6, 2000, pp. S172-S175

Abstract

Studies with conventional magnetic resonance imaging (MRI) support the hypothesis that cognitive impairment in multiple sclerosis (MS) patients is related with the lesion burden. Patterns of frontal lobe cognitive decline were also found to be related with the corresponding regional lesion load, although the total lesion load on T-2-weighted MRI scans of the brain seems to be more relevant in determining frontal lobe deficits. Other non-conventional MRI techniques with a higher specificity to the heterogeneous substrates of MS pathology, such as the assessment of hypointense lesion load on T-1-weighted scans and the histogram analysis of magnetisation transfer ratio(MTR) maps, have recently been applied to MS cognitive studies. Results from these studies suggest that three factors play a role in the pathogenesisof MS dementia: the burden of MS lesions, the severity of the pathologicaldamage within individual lesions and that of the normal-appearing white matter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:42:13