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Titolo:
Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats
Autore:
De Deurwaerdere, P; Chesselet, MF;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 20, anno: 2000,
pagine: 5170 - 5178
SICI:
0270-6474(20000701)20:13<5170:NLAODA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; NEONATAL 6-OHDA-LESIONED RATS; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; DOPAMINERGIC REGULATION; ELECTRICAL-STIMULATION; NEURONAL-ACTIVITY; GLOBUS-PALLIDUS;
Keywords:
Parkinson's disease; dyskinesia; dopamine; serotonin; basal ganglia; serotonin 2C receptors; c-Fos; m-CPP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Chesselet, MF Univ Calif Los Angeles, Sch Med, Dept Neurol, 710 Westwood Plaza, Los Angeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
P. De Deurwaerdere e M.F. Chesselet, "Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats", J NEUROSC, 20(13), 2000, pp. 5170-5178

Abstract

The loss of dopaminergic innervation of the basal ganglia, a group of subcortical regions involved in motor control, is the hallmark of Parkinson's disease. The resulting molecular and cellular alterations mediate behavioraldeficits and may modify neuronal responses to other neurotransmitters. In the present study, we sought to determine the effects of chronic dopamine (DA) depletion on responses mediated by stimulation of serotonergic 2C (5-HT2C) receptors, a serotonergic receptor subtype present in discrete regions of the basal ganglia. Specifically, the effects of unilateral lesions of nigrostriatal DA neurons on oral dyskinesia and Fos protein expression induced by the non-selective 5-HT2C agonist 1-(m-chlorophenyl)piperazine (m-CPP) were examined. Confirming previous findings, both peripheral and local injections of m-CPP into the subthalamic nucleus elicited oral dyskinesia. Nigrostriatal lesions markedly enhanced oral bouts induced by peripheral but not intrasubthalamic administration of m-CPP. In intact rats, Fos expression was increased by m-CPP (1 mg/kg, i.p.) in the striatum and the subthalamic nucleus. Afternigrostriatal lesions, m-CPP-induced Fos expression remained unchanged in the subthalamic nucleus but was reduced in the medial quadrants of the striatum and was markedly enhanced in the entopeduncular nucleus. These data demonstrate regionally specific alterations in behavioral and cellular responses to a serotonergic agonist in an animal model of Parkinson's disease.

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Documento generato il 16/07/20 alle ore 16:39:58