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Titolo:
Selective suppression of inhibitory synaptic transmission by nocistatin inthe rat spinal cord dorsal horn
Autore:
Zeilhofer, HU; Muth-Selbach, U; Guhring, H; Erb, K; Ahmadi, S;
Indirizzi:
Univ Erlangen Nurnberg, Dept Expt & Clin Pharmacol & Toxicol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 13, volume: 20, anno: 2000,
pagine: 4922 - 4929
SICI:
0270-6474(20000701)20:13<4922:SSOIST>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORPHANIN FQ NOCICEPTIN; GABA-IMMUNOREACTIVE PROFILES; FORMALIN TEST; RECEPTOR ANTAGONISTS; CALCIUM CHANNELS; AMINO-ACIDS; MICE; PRECURSOR; BRAIN; FQ/NOCICEPTIN;
Keywords:
nociceptin/orphanin FQ; nocistatin; nociception; pain; hyperalgesia; synaptic transmission; spinal cord slice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Zeilhofer, HU Inst Pharmacol & Toxicol, Winterthurerstr 190, CH-8057 Zurich, Switzerland Inst Pharmacol & Toxicol Winterthurerstr 190 Zurich Switzerland CH-8057
Citazione:
H.U. Zeilhofer et al., "Selective suppression of inhibitory synaptic transmission by nocistatin inthe rat spinal cord dorsal horn", J NEUROSC, 20(13), 2000, pp. 4922-4929

Abstract

Nociceptin/orphanin FQ (N/OFQ) and nocistatin (NST) are two recently identified neuropeptides with opposing effects on several CNS functions, including spinal nociception. The cellular mechanisms that underlie this antagonism are not known. Here, we have investigated the effects of both peptides onsynaptic transmission mediated by the three fast neurotransmitters L-glutamate, glycine, and GABA in the superficial layers of the rat spinal cord horn, which constitute the first important site of integration of nociceptiveinformation in the pain pathway. NST selectively reduced transmitter release from inhibitory interneurons via a presynaptic Bordetella pertussis toxin-sensitive mechanism but left excitatory glutamatergic transmission unaffected. In contrast, N/OFQ only inhibited excitatory transmission. In the ratformalin test, an animal model of tonic pain in which N/OFQ exerts antinociceptive activity, NST induced profound hyperalgesia after intrathecal application. Similar to glycine and GABAA receptor antagonists, NST had no significant effects in the rat tail-flick test, a model of acute thermal pain. Our results provide a cellular basis for the antagonism of N/OFQ and NST and suggest the existence of a so far unidentified membrane receptor for NST. In addition, they support a role of NST as an endogenous inhibitor of glycinergic and GABAergic neurotransmission in the sensory part of the spinal cord and as a mediator of spinal hyperalgesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 16:05:21