Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The endogenous amine 1-methyl-1,2,3,4-tetrahydroisoquinoline prevents the inhibition of complex I of the respiratory chain produced by MPP+
Autore:
Parrado, J; Absi, E; Ayala, A; Castano, A; Cano, J; Machado, A;
Indirizzi:
Univ Sevilla, Fac Farm, Dept Bioquim Bromatol & Toxicol, E-41012 Seville, Spain Univ Sevilla Seville Spain E-41012 tol & Toxicol, E-41012 Seville, Spain
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 75, anno: 2000,
pagine: 65 - 71
SICI:
0022-3042(200007)75:1<65:TEA1PT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; IRREVERSIBLE INHIBITION; IDIOPATHIC PARKINSONISM; DOPAMINE TRANSPORTER; NADH DEHYDROGENASE; ASCORBIC-ACID; MOUSE-BRAIN; RAT-BRAIN; TETRAHYDROISOQUINOLINE; MPTP;
Keywords:
1-methyl-1,2,3,4-tetrahydroisoquinoline; MPP+; Parkinson's disease; mitochondria; complex I; dopaminergic neurotoxin; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Machado, A Univ Sevilla, Fac Farm, Dept Bioquim Bromatol & Toxicol, C-O Prof Garcia Gonzalez S-N, E-41012 Seville, Spain Univ Sevilla C-O Prof GarciaGonzalez S-N Seville Spain E-41012
Citazione:
J. Parrado et al., "The endogenous amine 1-methyl-1,2,3,4-tetrahydroisoquinoline prevents the inhibition of complex I of the respiratory chain produced by MPP+", J NEUROCHEM, 75(1), 2000, pp. 65-71

Abstract

The endogenous monoamine 1-methyl-1,2,3,4-tetrahydroisoquinoline has been shown to prevent the neurotoxic effect of MPP+ and other endogenous neurotoxins, which produce a parkinsonian-like syndrome in humans. We have tested its potential protective effect in vivo by measuring the protection of 1-methyl-1,2,3,4-tetrahydroisoquinoline in the neurotoxicity elicited by MPP+ in rat striatum by tyrosine hydroxylase immunocytochemistry. Because we knowthat cellular damage caused by MPP+ is primarily the result of mitochondrial respiratory inhibition at the complex I lever, we have extended the study further to understand this protective mechanism. We found that the inhibitory effect on the mitochondrial respiration rate induced by MPP+ in isolated rat liver mitochondria and striatal synaptosomes was prevented by addition of 1-methyl-1,2,3,4-tetrahydroisoquinoline. This compound has no antioxidant capacity; therefore, this property is not involved in its protective effect. Thus, we postulate that the preventive effect that 1-methyl-1,2,3,4-tetrahydroisoquinoline has on mitochondrial inhibition for MPP+ could be due to a "shielding effect," protecting the energetic machinery, thus preventing energetic failure. These results suggest that this endogenous amine mayprotect against the effect of several parkinsonism-inducing compounds thatare associated with progressive impairment of the mitochondrial function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:45:18