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Titolo:
ONTOGENY OF GROWTH-HORMONE AND LH-BETA-SUBUNIT, FSH-BETA-SUBUNIT AND ALPHA-SUBUNIT MESSENGER-RNA LEVELS IN THE PORCINE FETAL AND NEONATAL ANTERIOR-PITUITARY
Autore:
GRANZ S; ELLENDORFF F; GROSSMANN R; KATO Y; ELSAESSER F;
Indirizzi:
INST ANIM HUSB & ANIM BEHAV,MARIENSEE D-31535 NEUSTADT GERMANY INST ANIM HUSB & ANIM BEHAV D-31535 NEUSTADT GERMANY INST SMALL ANIM RES D-29223 CELLE GERMANY GUNMA UNIV,INST MOL & CELLULAR REGULAT GUNMA 371 JAPAN
Titolo Testata:
Journal of neuroendocrinology
fascicolo: 6, volume: 9, anno: 1997,
pagine: 439 - 449
SICI:
0953-8194(1997)9:6<439:OOGALF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM TESTOSTERONE CONCENTRATIONS; GONADOTROPIN-RELEASING-HORMONE; RIBONUCLEIC-ACID LEVELS; CATHETERIZED PIG FETUS; DNA-SEQUENCE ANALYSIS; LUTEINIZING-HORMONE; MESSENGER-RNA; SEXUAL-DIFFERENTIATION; SECRETORY PATTERNS; MOLECULAR-BIOLOGY;
Keywords:
MESSENGER-RNA LEVEL; FETAL DEVELOPMENT; PIG; GROWTH HORMONE; GONADOTROPINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
S. Granz et al., "ONTOGENY OF GROWTH-HORMONE AND LH-BETA-SUBUNIT, FSH-BETA-SUBUNIT AND ALPHA-SUBUNIT MESSENGER-RNA LEVELS IN THE PORCINE FETAL AND NEONATAL ANTERIOR-PITUITARY", Journal of neuroendocrinology, 9(6), 1997, pp. 439-449

Abstract

The mechanism underlying the ontogenetic increase in plasma growth hormone (GH), luteinizing hormone (LH) and follicle stimulating hormone (FSH) concentration during fetal life in mammalian species and the prenatal sex difference in these hormones in some species is not fully understood, To this end anterior pituitaries were collected from German Landrace fetuses and piglets at day (d) 50, 65, 80, 95, 110 pc and d 6pp and pituitary GH, LH beta, FSH beta and alpha-subunit mRNA levels were determined by measuring Northern blot hybridization signals. GH mRNA was detected in both sexes as early as d 50 pc, The mRNA level markedly increased with age in both sexes (males>females, P less than or equal to 0.05) reaching its maximum at d 95/110 pc, LH beta mRNA signals were first detected at d 50 pc in females and at d 65 pc in males increasing thereafter to a maximum at d 6 pp in both sexes (P less thanor equal to 0.05). In males the augmentation in LH beta mRNA was delayed compared to females (P less than or equal to 0.01). Before d 80 pcno FSH beta mRNA hybridization signals were apparent. Thereafter the mRNA level continuously increased with age (P less than or equal to 0.01) in both sexes reaching its maximum at d 6 pp. The FSH beta mRNA level in females was always higher than in males (P less than or equal to 0.01). As early as d 50 pc the alpha-subunit mRNA level was high in both sexes and further increased without sex difference to d 6 pp (P less than or equal to 0.05). In conclusion, the mRNA levels of GH, LH beta and FSH beta are age and sex dependent during fetal development, We suggest that the fetal increase in plasma GH concentration can be accounted for by changes in GH mRNA levels, while the dramatic perinataldecrease in plasma GH concentration seems to be primarily controlled at the posttranslational and/or secretion level, The fetal sex difference and the increase in plasma LH and FSH concentrations seems to be primarily dependent on the cellular concentration of the gonadotropin beta-subunit mRNAs and/or number of gonadotrophs.

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Documento generato il 01/12/20 alle ore 08:10:46