Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Antibody spectrum against the viral transactivator protein in patients with human immunodeficiency virus type 1 infection and Kaposi's sarcoma
Autore:
Demirhan, I; Chandra, A; Mueller, F; Mueller, H; Biberfeld, P; Hasselmayer, O; Chandra, P;
Indirizzi:
Univ Frankfurt, Sch Med, ZBC,Gustav Embden Ctr Biol Chem, Head Mol Biol,Dept Mol Biol, D-60590 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60590 iol, D-60590 Frankfurt, Germany Dr Horst Schmidt Hosp, Inst Pathol, Wiesbaden, Germany Dr Horst Schmidt Hosp Wiesbaden Germany Inst Pathol, Wiesbaden, Germany Karolinska Inst, Stockholm, Sweden Karolinska Inst Stockholm SwedenKarolinska Inst, Stockholm, Sweden
Titolo Testata:
JOURNAL OF HUMAN VIROLOGY
fascicolo: 3, volume: 3, anno: 2000,
pagine: 137 - 143
SICI:
1090-9508(200005/06)3:3<137:ASATVT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-1 TAT PROTEIN; MONOCLONAL-ANTIBODIES; T-CELLS; APOPTOSIS; INTEGRINS; DOMAIN;
Keywords:
anti-tat IgG; HIV-1 infection; Kaposi's sarcoma; passive immunization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Chandra, P Univ Frankfurt, Sch Med, ZBC,Gustav Embden Ctr Biol Chem, Head Mol Biol,Dept Mol Biol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590 y
Citazione:
I. Demirhan et al., "Antibody spectrum against the viral transactivator protein in patients with human immunodeficiency virus type 1 infection and Kaposi's sarcoma", J HUMAN VIR, 3(3), 2000, pp. 137-143

Abstract

We analyzed patterns of antibody response to recombinant transactivator protein (human Immunodeficiency virus type 1 [HIV-1] tat) in serum samples from HIV-1-negative subjects (n = 60), HIV-1-infected asymptomatic patients (n = 20), HTV-1-infected patients with Kaposi's sarcoma (n = 25), and patients with Kaposi's sarcoma without HN-I infection. None of the: healthy subjects possessed antitat immunoglobulin G (IgG) in their serum. AU asymptomatic patients with HN-I infection were anti-tar IgG-positive. Epitope mapping revealed that these sera had anti-rat IgG to all the functional domains of tar protein. Histochemical studies on lymph nodes from five asymptomatic HIV-1-infected patients showed that, in all cases, rat-positive cells were present within the germinal center at the stage of follicular fragmentation containing immunoblasts and small lymphocytes. Of the 25 HIV-1-infected patients with Kaposi's sarcoma, 4 were anti-tar TgG-positive; however, the epitope analysis revealed that IgG to functional domains of tar protein-in particular to transactivating response element (TAR)binding site-were absent. All patients with Kaposi's sarcoma without HIV-1 infection were anti-rat IgG-negative. Presence or absence of anti-rat IgG and a prevalence of different antibody profiles in different groups of patients indicated the pathophysiologic role of rat protein. Thus, a passive immunization with anti-tar IgGcould be a useful strategy to influence the pathophysiologic state of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 16:47:16