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Titolo:
A porcine model of carotid artery thrombosis for thrombolytic therapy and angioplasty: Application of PTFE graft-induced stenosis
Autore:
Lin, PH; Chen, CY; Surowiec, SM; Conklin, B; Bush, RL; Chaikof, EL; Lumsden, AB; Weiss, V;
Indirizzi:
Emory Univ, Div Vasc Surg, Dept Surg, Sch Med, Atlanta, GA 30322 USA EmoryUniv Atlanta GA USA 30322 Dept Surg, Sch Med, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF ENDOVASCULAR THERAPY
fascicolo: 3, volume: 7, anno: 2000,
pagine: 227 - 235
SICI:
1526-6028(200006)7:3<227:APMOCA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERIES; CANINE MODEL; OCCLUSION; AGENTS; PIG;
Keywords:
animal model; urokinase; heparin; balloon angioplasty; carotid stenosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lumsden, AB Emory Univ, Div Vasc Surg, Dept Surg, Sch Med, 1364 Clifton RdNE,Suite H124A, Atlanta, GA 30322 USA Emory Univ 1364 Clifton Rd NE,Suite H124A Atlanta GA USA 30322
Citazione:
P.H. Lin et al., "A porcine model of carotid artery thrombosis for thrombolytic therapy and angioplasty: Application of PTFE graft-induced stenosis", J ENDOVAS T, 7(3), 2000, pp. 227-235

Abstract

Purpose: To develop a porcine carotid artery thrombosis model for the evaluation of thrombolytic therapy and adjunctive angioplasty procedures. Methods: Bilateral carotid thrombosis was induced in 16 pigs using endothelial crush injury followed by external polytetrafluoroethylene (PTFE, 5 x 2cm(2)) wrap placement to create segmental carotid stenosis. Light microscopy was used to examine thrombus composition. Selective carotid catheterization was performed via a femoral approach. Two hours following carotid artery occlusion, a urokinase (250,000 IU) and heparin (1000 U) solution was pulse-sprayed in 1 carotid artery while the contralateral vessel received the control saline vehicle. The efficacy of thrombolytic therapy was assessed using carotid arteriography and intravascular ultrasound. The feasibility and technical efficacy of balloon angioplasty within the carotid stenosis model were also evaluated. Results: Carotid artery occlusion occurred in 30 +/- 6 minutes following endothelial injury plus PTFE wrap placement. Histotogical examination of carotid arteries showed endothelial irregularity with fibrin-rich and platelet-rich thrombus. Urokinase was effective in recanalizing all occluded arteries (100%), white the control saline vehicle showed no effective thrombolysis (p < 0.001). Angioplasty was successful in restoring normal diameter in all arteries (100%). Conclusions: This carotid artery thrombosis model, which incorporates intimal injury with segmental stenosis, is simple to create and reproducible. tt provides not only a model for the evaluation of thrombolytic therapy but also a practical training tool for adjunctive endovascular interventions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:42:34