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Titolo:
The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats
Autore:
Svensson, J; Lall, S; Dickson, SL; Bengtsson, BA; Romer, J; Ahnfelt-Ronne, I; Ohlsson, C; Jansson, JO;
Indirizzi:
Sahlgrenska Univ Hosp, Res Ctr Endocrinol & Metab, SE-41345 Gothenburg, Sweden Sahlgrenska Univ Hosp Gothenburg Sweden SE-41345 1345 Gothenburg, Sweden Univ Cambridge, Dept Physiol, Cambridge, England Univ Cambridge Cambridge England idge, Dept Physiol, Cambridge, England Novo Nordisk AS, Hlth Care Discovery, DK-2880 Bagsvaerd, Denmark Novo Nordisk AS Bagsvaerd Denmark DK-2880 ry, DK-2880 Bagsvaerd, Denmark
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 3, volume: 165, anno: 2000,
pagine: 569 - 577
SICI:
0022-0795(200006)165:3<569:TGSIAG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE (GH)-RELEASING PEPTIDE; HUMAN GROWTH-HORMONE; OSTEOBLAST-LIKE CELLS; CORTICAL BONE; AGED RATS; FACTOR-I; SECRETION; PITUITARY; DENSITY; SPACEFLIGHT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Svensson, J Sahlgrenska Univ Hosp, Res Ctr Endocrinol & Metab, Grona Straket 8, SE-41345 Gothenburg, Sweden Sahlgrenska Univ Hosp Grona Straket 8 Gothenburg Sweden SE-41345
Citazione:
J. Svensson et al., "The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats", J ENDOCR, 165(3), 2000, pp. 569-577

Abstract

Growth hormone (GH) is of importance for normal bone remodelling. A recentclinical study demonstrated that MK-677, a member of a class of GH secretagogues (GHSs), increases serum concentrations of biochemical markers of bone formation and bone resorption. The aim of the present study was to investigate whether the GHSs, ipamorelin (IPA) and GH-releasing peptide-6 (GHRP-6), increase bone mineral content (BMC) in young adult female rats. Thirteen-week-old female Sprague-Dawley rats were given IPA (0.5 mg/kg per day; n =7), GHRP-6 (0.5 mg/kg per day; n = 8), GH (3.5 mg/kg per day; n = 7), or vehicle administered continuously s.c. via osmotic minipumps for 12 weeks. The animals were followed in vivo by dual X-ray absorptiometry (DXA) measurements every 4th week. After the animals were killed, femurs were analysed in vitro by mid-diaphyseal peripheral quantitative computed tomography (pQCT) scans. After this, excised femurs and vertebrae L6 were analysed by the use of Archimedes' principle and by determinations of ash weights. All treatments increased body weight and total tibial and vertebral BMC measured by DXA in vivo compared with vehicle-treated controls. However, total BMC corrected for the increase in body weight (total BMC:body weight ratio) was unaffected. Tibial area bone mineral density (BMD, BMC/area) was increased, but total and vertebral area BMDs were unchanged. The pQCT measurements in vitro revealed that the increase in the cortical BMC was due to an increased cross-sectional bone area, whereas the cortical volumetric BMD was unchanged. Femur and vertebra L6 volumes were increased but no effect was seen on the volumetric BMDs as measured by Archimedes' principle. Ash weight was increased by all treatments, but the mineral concentration was unchanged. We conclude that treatment of adult female rats with the GHSs ipamorelin and GHRP-6 increases BMC as measured by DXA in viva. The results of in vitro measurements using pQCT and Archimedes' principle, in addition to ash weight determinations, show that the increases in cortical and total BMC were due toan increased growth of the bones with increased bone dimensions, whereas the volumetric BMD was unchanged.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:00:56