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Titolo:
Predominant information transfer from layer III pyramidal neurons to corticospinal neurons
Autore:
Kaneko, T; Cho, RH; Li, YQ; Nomura, S; Mizuno, N;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Morphol Brain Sci, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 t Morphol Brain Sci, Kyoto 6068501, Japan Kyoto Univ, Japan Sci & Technol, CREST, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 ci & Technol, CREST, Kyoto 6068501, Japan Kyoto Univ, Coll Med Technol, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 v, Coll Med Technol, Kyoto 6068501, Japan
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 423, anno: 2000,
pagine: 52 - 65
SICI:
0021-9967(20000717)423:1<52:PITFLI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABA-IMMUNOREACTIVE NEURONS; LONG-TERM POTENTIATION; CAT MOTOR CORTEX; CALCIUM-BINDING PROTEINS; RAT CEREBRAL-CORTEX; VISUAL-CORTEX; SENSORY CORTEX; SYNAPTIC RELATIONSHIPS; MONOCLONAL-ANTIBODIES; SOMATOSENSORY CORTEX;
Keywords:
local circuit; axon collateral; intracellular staining; corticothalamic neurons; evoked potential; motor cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Kaneko, T Kyoto Univ, Grad Sch Med, Dept Morphol Brain Sci, Kyoto 6068501,Japan Kyoto Univ Kyoto Japan 6068501 Brain Sci, Kyoto 6068501, Japan
Citazione:
T. Kaneko et al., "Predominant information transfer from layer III pyramidal neurons to corticospinal neurons", J COMP NEUR, 423(1), 2000, pp. 52-65

Abstract

Connections of layer III pyramidal neurons to corticospinal neurons of layer V and corticothalamic neurons of layer VI in the rat primary motor cortex were examined in brain slices by combining intracellular staining with Golgi-like retrograde labeling of corticofugal neurons. Forty layer III pyramidal neurons stained intracellularly were of the regular-spiking type, showed immunoreactivity for glutaminase, and emitted axon collaterals arborizing locally in layers II/III and/or V. Nine of them were reconstructed for morphologic analysis; 15.2% or 3.8% of varicosities of axon collaterals of the reconstructed neurons were apposed to dendrites of corticospinal or corticothalamic neurons, respectively. By confocal laser scanning and electron microscopy, some of these appositions were revealed to make synapses. These findings suggest that corticospinal neurons receive information from the superficial cortical layers four times more frequently than corticothalamic neurons. The connections were further examined by intracellular recording ofexcitatory postsynaptic potential (EPSP) that were evoked in layer V and layer VI pyramidal neurons by stimulation of layer II/III. EPSPs evoked in layer V pyramidal neurons showed short and constant onset latencies, suggesting their monosynaptic nature. In contrast, most EPSPs evoked in layer VI pyramidal neurons had long onset latencies, showed double-shock facilitationof onset latency, and were largely suppressed by an N-methyl-D-aspartic acid receptor blocker, suggesting that they were polysynaptic. The results suggest that information from the superficial cortical layers is transferred directly and efficient;ly to corticospinal neurons in layer V and thereby exerts an important influence on cortical motor output. Corticothalamic neurons are, in contrast, considered relatively independent of, or indirectly related to, information processing of the superficial cortical layers. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 07/04/20 alle ore 00:07:18