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Titolo:
Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
Autore:
Shaw, PX; Horkko, S; Chang, MK; Curtiss, LK; Palinski, W; Silverman, GJ; Witztum, JL;
Indirizzi:
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA Scripps Clin & Res Fdn, Res Inst, La Jolla, CA 92037 USA Scripps Clin & Res Fdn La Jolla CA USA 92037 Inst, La Jolla, CA 92037 USA
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 12, volume: 105, anno: 2000,
pagine: 1731 - 1740
SICI:
0021-9738(200006)105:12<1731:NAWTTI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; OXIDATION-SPECIFIC EPITOPES; RECEPTOR-DEFICIENT MICE; MONOCLONAL-ANTIBODIES; B-CELLS; ANTIPHOSPHOLIPID ANTIBODIES; OXIDIZED PHOSPHOLIPIDS; POSITIVE SELECTION; ANTIGEN-BINDING; HIGH TITERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Witztum, JL Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 USA
Citazione:
P.X. Shaw et al., "Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity", J CLIN INV, 105(12), 2000, pp. 1731-1740

Abstract

The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, me isolated a panel of oxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation-specific epitopes on apoptotic cells, and are deposited in atherosclerotic lesions. The Abs were found to be structurally and functionally identical to classic "natural" T15 anti-PC Abs that are of B-1cell origin and are reported to provide optimal protection from virulent pneumococcal infection. These findings suggest that there has been natural selection for B-1 cells secreting oxidation-specific/T15 antibodies, both for their role in natural immune defense and for housekeeping roles against oxidation-dependent neodeterminants in health and disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:09:11