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Titolo:
Brain tumor demarcation using optical spectroscopy; an in vitro study
Autore:
Lin, WC; Toms, SA; Motamedi, M; Jansen, ED; Mahadevan-Jansen, A;
Indirizzi:
Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA Vanderbilt Univ Nashville TN USA 37235 omed Engn, Nashville, TN 37235 USA Univ Texas, Med Branch, Ctr Biomed Engn, Jennie Sealy Hosp 621, Galveston,TX 77550 USA Univ Texas Galveston TX USA 77550 Sealy Hosp 621, Galveston,TX 77550 USA Vanderbilt Med Ctr, Dept Neurol Surg, Nashville, TN 37332 USA Vanderbilt Med Ctr Nashville TN USA 37332 l Surg, Nashville, TN 37332 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL OPTICS
fascicolo: 2, volume: 5, anno: 2000,
pagine: 214 - 220
SICI:
1083-3668(200004)5:2<214:BTDUOS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-INDUCED FLUORESCENCE; INTRAOPERATIVE DELINEATION; TISSUE AUTOFLUORESCENCE; INTRINSIC FLUORESCENCE; SURGICAL RESECTION; MALIGNANT GLIOMAS; IN-VIVO; ULTRASOUND; DIAGNOSIS; MARGINS;
Keywords:
autofluorescence; diffuse reflectance; brain tumor margin detection; tissue diagnosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Engineering, Computing & Technology
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Mahadevan-Jansen, A Vanderbilt Univ, Dept Biomed Engn, Box 1631,Stn B, Nashville, TN 37235 USA Vanderbilt Univ Box 1631,Stn B Nashville TN USA 37235
Citazione:
W.C. Lin et al., "Brain tumor demarcation using optical spectroscopy; an in vitro study", J BIOMED OP, 5(2), 2000, pp. 214-220

Abstract

Optical spectroscopy for brain tumor demarcation was investigated in this study. Fluorescence and diffuse reflectance spectra were measured from normal and tumorous human brain tissues in vitro. A fluorescence peak was consistently observed around 460 nm (+/-10 nm) emission from both normal and tumorous brain tissues using 337 nm excitation. Intensity of this fluorescencepeak ( F-460) from normal brain tissues was greater than that from primarybrain tumorous tissues. In addition, diffuse reflectance (Rd) between 650 and 800 nm from white matter was significantly stronger than that from primary and secondary brain tumors. A good separation between gray matter and brain rumors was found using the ratio of F-460 and Rd at 460 nm (Rd(460)) TWO empirical discrimination algorithms based on F-460, Rd(625), and F-460/Rd(460) were developed. These algorithms yielded an average sensitivity and specificity of 96% and 93%, respectively. (C) 2000 society of Photo-OpticalInstrumentation Engineers. [S1083-3668(00)00602-X].

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Documento generato il 02/12/20 alle ore 14:41:05