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Titolo:
Accelerated Publication - Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules
Autore:
Gu, YJ; Ihara, Y;
Indirizzi:
Univ Tokyo, Fac Med, Dept Neuropathol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ropathol, Bunkyo Ku, Tokyo 1130033, Japan Japan Sci & Technol Corp, JSP, CREST, Kawaguchi 3320012, Japan Japan Sci &Technol Corp Kawaguchi Japan 3320012 awaguchi 3320012, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 24, volume: 275, anno: 2000,
pagine: 17917 - 17920
SICI:
0021-9258(20000616)275:24<17917:AP-ETC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH CONE COLLAPSE; AXONAL GUIDANCE; OUTGROWTH; UNC-33; FAMILY; DIHYDROPYRIMIDINASE; NEURONS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Ihara, Y Univ Tokyo, Fac Med, Dept Neuropathol, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 Tokyo 1130033, Japan
Citazione:
Y.J. Gu e Y. Ihara, "Accelerated Publication - Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules", J BIOL CHEM, 275(24), 2000, pp. 17917-17920

Abstract

Collapsin response mediator protein-2 (CRMP-2) is a member of the CRMP/TOAD/Ulip/DRP family of cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP-2 mediates the intracellular response tocollapsin 1/semaphorin 3A, a repulsive extracellular guidance cue for axonal outgrowth. The mutation of UNC-33, a Caenorhabditis elegans homolog of CRMP-2, results in abnormality of microtubules in neurites, but the mechanism of CRMP-2 action remains to be clarified. Here, we report that overexpression of human CRMP-2 in Neuro2a cells, a mouse neuroblastoma cell line, results in blebbing of the cytoplasm. Furthermore, some cells exhibited intranuclear inclusions, which were labeled with antibodies to CRMP-2 and tubulin, CRMP-2 was found to be associated with microtubule bundles in the spindles at the metaphase and in the midbodies at the late telophase in mitotic cells. Thus, it is most likely that failure of complete disassembly of the spindle microtubules during mitosis is responsible for the formation of theseintranuclear inclusions. We suggest that CRMP-2 functions by regulating the dynamics of microtubules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:46:37