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Titolo:
Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind
Autore:
Yamaguchi, F; Saito, M; Ariga, T; Yoshimura, Y; Nakazawa, H;
Indirizzi:
Kikkoman Corp, Div Res & Dev, Noda, Chiba 2780037, Japan Kikkoman Corp Noda Chiba Japan 2780037 & Dev, Noda, Chiba 2780037, Japan Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 Chem, Shinagawa Ku, Tokyo 1428501, Japan
Titolo Testata:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
fascicolo: 6, volume: 48, anno: 2000,
pagine: 2320 - 2325
SICI:
0021-8561(200006)48:6<2320:FRSAAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED GASTRIC-ULCERATION; ELECTRON-SPIN-RESONANCE; GRAPE SEED EXTRACT; IN-VITRO; H2O2/NAOH/DMSO SYSTEM; HEART-DISEASE; ANTIOXIDANTS; OXYGEN; OXIDATION; INJURY;
Keywords:
garcinol; Garcinia indica; reactive oxygen species; electron spin resonance; antiulcer activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, F Kikkoman Corp, Div Res & Dev, Noda 399, Noda, Chiba 2780037, Japan Kikkoman Corp Noda 399 Noda Chiba Japan 2780037 780037, Japan
Citazione:
F. Yamaguchi et al., "Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind", J AGR FOOD, 48(6), 2000, pp. 2320-2325

Abstract

Garcinol, a polyisoprenylated benzophenone derivative, was purified from Garcinia indica fruit rind, and its free radical scavenging activity was studied using electron spin resonance (ESR) spectrometry. In the hypoxanthine/xanthine oxidase system, emulsified garcinol suppressed superoxide anion toalmost the same extent as DL-alpha-tocopherol by weight. In the Fenton reaction system, garcinol also suppressed hydroxyl radical more strongly than DL-alpha-tocopherol. In the H2O2/NaOH/DMSO system, garcinol suppressed superoxide anion, hydroxyl radical, and methyl radical. It was thus confirmed that this derivative is a potent free radical scavenger and able to scavengeboth hydrophilic and hydrophobic ones including reactive oxygen species. Orally administered garcinol prevented acute ulceration in rats induced by indomethacin and water immersion stress caused by radical formation. These results suggested garcinol might have potential as a free radical scavenger and clinical application as an antiulcer drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:33:48