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Titolo:
Botulinum toxin C3 inhibits hyperalgesia in mice with partial sciatic nerve injury
Autore:
Ye, X; Inoue, H; Ueda, H;
Indirizzi:
Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, Nagasaki8528521, Japan Nagasaki Univ Nagasaki Japan 8528521 & Neurosci, Nagasaki8528521, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 83, anno: 2000,
pagine: 161 - 163
SICI:
0021-5198(200006)83:2<161:BTCIHI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ENDOTHELIAL-CELLS; NEUROPATHIC PAIN; RHO; EXPRESSION; ADHESION; MODEL;
Keywords:
botulinum toxin C3; hyperalgesia; sciatic nerve injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Ueda, H Nagasaki Univ, Sch Pharmaceut Sci, Dept Mol Pharmacol & Neurosci, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan Nagasaki Univ 1-14 Bunkyo Machi Nagasaki Japan 8528521 521, Japan
Citazione:
X. Ye et al., "Botulinum toxin C3 inhibits hyperalgesia in mice with partial sciatic nerve injury", JPN J PHARM, 83(2), 2000, pp. 161-163

Abstract

Mice with partial ligation of the sciatic nerve exhibited marked increase in the second phase nociceptive biting and licking behavior following intraplantar injection of formalin. The intrathecal pretreatment with botulinum toxin C3 dose-dependently attenuated the hyperalgesia in the second phase. These results suggest that a small G protein, Rho, and its downstream mechanisms are involved in the hyperalgesia following partial nerve injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:36:45