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Titolo:
Low interleukin-12 activity in severe Plasmodium falciparum malaria
Autore:
Luty, AJF; Perkins, DJ; Lell, B; Schmidt-Ott, R; Lehman, LG; Luckner, D; Greve, B; Matousek, P; Herbich, K; Schmid, D; Weinberg, JB; Kremsner, PG;
Indirizzi:
Univ Tubingen, Inst Trop Med, Dept Parasitol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 asitol, D-72074 Tubingen, Germany Vet Affairs Med Ctr, Dept Med, Durham, NC 27005 USA Vet Affairs Med Ctr Durham NC USA 27005 r, Dept Med, Durham, NC 27005 USA Duke Univ, Med Ctr, Durham, NC 27005 USA Duke Univ Durham NC USA 27005Duke Univ, Med Ctr, Durham, NC 27005 USA Albert Schweitzer Hosp, Res Unit, Lambarene, Gabon Albert Schweitzer HospLambarene Gabon Hosp, Res Unit, Lambarene, Gabon Univ Vienna, Dept Infect Dis, Vienna, Austria Univ Vienna Vienna Austria niv Vienna, Dept Infect Dis, Vienna, Austria
Titolo Testata:
INFECTION AND IMMUNITY
fascicolo: 7, volume: 68, anno: 2000,
pagine: 3909 - 3915
SICI:
0019-9567(200007)68:7<3909:LIAISP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SUSCEPTIBLE A/J MICE; INTERFERON-GAMMA; FACTOR-ALPHA; T-CELLS; IN-VIVO; CYTOKINE PRODUCTION; IMMUNE-RESPONSES; MURINE MALARIA; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Luty, AJF Univ Tubingen, Inst Trop Med, Dept Parasitol, Wilhelmstr 27, D-72074 Tubingen, Germany Univ Tubingen Wilhelmstr 27 Tubingen Germany D-72074 n, Germany
Citazione:
A.J.F. Luty et al., "Low interleukin-12 activity in severe Plasmodium falciparum malaria", INFEC IMMUN, 68(7), 2000, pp. 3909-3915

Abstract

We compared interleukin-12 (IL-12) and other cytokine activities during and after an acute clinical episode in a matched-pair case-control study of young African children who presented with either mild or severe Plasmodium falciparum malaria. The acute-phase, pretreatment plasma IL-12 and alpha interferon (IFN-alpha) levels, as well as the acute-phase mitogen-stimulated whole-blood production capacity of IL-12, were significantly lower in children with severe rather than mild malaria. IL-12 levels, in addition, showed strong inverse correlations both with parasitemia and with the numbers of circulating malaria pigment containing neutrophils. Acute-phase plasma tumornecrosis factor (TNF) and IL-10 levels were significantly higher in those with severe malaria, and the concentrations of both of these cytokines werepositively correlated both with parasitemia and with the numbers of pigment-containing phagocytes in the blood. Children with severe anemia had the highest levels of TNF in plasma. In all the children, the levels in plasma and production capacities of all cytokines normalized when they were healthyand parasite free. The results indicate that severe but not mild P, falciparum malaria in young, nonimmune African children is characterized by down-regulated IL-12 activity, contrasting markedly with the up-regulation of both TNF and IL-10 in the same children. A combination of disturbed phagocytefunctions resulting from hemozoin consumption, along with reduced IFN-gamma responses, may contribute to these differential effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:36:10