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Titolo:
Cell cycle regulators in bladder cancer: A multivariate survival study with emphasis on p27Kip1
Autore:
Korkolopoulou, P; Christodoulou, P; Konstantinidou, AE; Thomas-Tsagli, E; Kapralos, P; Davaris, P;
Indirizzi:
Natl Tech Univ Athens, Dept Pathol, GR-10682 Athens, Greece Natl Tech UnivAthens Athens Greece GR-10682 ol, GR-10682 Athens, Greece Asklepeion Hosp, Dept Pathol, Athens, Greece Asklepeion Hosp Athens Greece lepeion Hosp, Dept Pathol, Athens, Greece Asklepeion Hosp, Dept Urol, Athens, Greece Asklepeion Hosp Athens Greece sklepeion Hosp, Dept Urol, Athens, Greece
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 6, volume: 31, anno: 2000,
pagine: 751 - 760
SICI:
0046-8177(200006)31:6<751:CCRIBC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT KINASE INHIBITOR; PROTEIN EXPRESSION; PROGNOSTIC VALUE; P27(KIP1) EXPRESSION; POTENTIAL MEDIATOR; TUMOR PROGRESSION; SUPPRESSOR GENES; P53; CARCINOMA; P27;
Keywords:
p21; p27; p16; pRb; bladder cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Korkolopoulou, P 73 Vassileos Pavlou Str, Athens 15452, Greece 73 Vassileos Pavlou Str Athens Greece 15452 452, Greece
Citazione:
P. Korkolopoulou et al., "Cell cycle regulators in bladder cancer: A multivariate survival study with emphasis on p27Kip1", HUMAN PATH, 31(6), 2000, pp. 751-760

Abstract

Cyclin-dependent kinase inhibitors (CKIs) prevent cyclin-dependent kinasesfrom phosphorylating critical substrates such as retinoblastoma gene protein (pRb), hence blocking the cascade of events leading to cell proliferation. Currently, the list of CKIs includes p21WAF1/Cip1, p27Kip1, p57Kip2 (theCip/Kip family), p15/INK4b, p16/INK4a, p18/INK4c, and p19/INK4d (the INK4 family). Among them, p27 plays a crucial role inning extracellular growth-regulatory signals to progression to or exit from the cell cycle. Unlike p53, p16, and Rb, mutations in Kip1 and WAF1 genes are distinctly rare in bladder cancer. We analyzed immunohistochemically the expression of p27 and other interacting G1 proteins (ie, p21, p16, pRb, p53) in 120 consecutive cases of transitional cell carcinomas (TCCs) and related it to proliferation rate, clinicopathologic parameters, and survival. p27 levels were significantly higher in low-grade (P = .001), superficial (Ta-T1) (P = .001), papillary (P < .001), and slowly proliferating TCCs (r(s) = -0.235, P = .05). p27 also positively correlated with p16 expression (r(s) = 0.212, P = .05). In univariate analysis, decreased p27 expression was associated with poor overall (P = .0100) and postrelapse (P = .0344) survival, especially if combinedto increased Ki-67 expression (P = .0004 and P = .036, respectively). Furthermore, in multivariate analysis, Ki-67/p27 status had the strongest hearing on the overall survival of muscle-invasive TCCs (P = .0019). Our resultsindicate that low p27 expression is more common in poorly differentiated muscle-invasive TCCs and is a major player in cell cycle control in these neoplasms. More importantly, the combined Ki-67/p27 expression provides prognostic information beyond that provided by conventional parameters or other cell cycle-related proteins, concerning overall survival in muscle-invasiveTCCs. HUM PATHOL 31:751-760. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:24:57