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Titolo:
The effects of highly selective opioid receptor antagonists on the releaseof arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection
Autore:
Sasaki, T; Arakawa, K; Shimada, K; Saito, N;
Indirizzi:
Nagoya Univ, Grad Sch Bioagr Sci, Physiol Anim Lab, Nagoya, Aichi 4648601,Japan Nagoya Univ Nagoya Aichi Japan 4648601 m Lab, Nagoya, Aichi 4648601,Japan
Titolo Testata:
GENERAL AND COMPARATIVE ENDOCRINOLOGY
fascicolo: 3, volume: 118, anno: 2000,
pagine: 365 - 372
SICI:
0016-6480(200006)118:3<365:TEOHSO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHICKENS GALLUS-DOMESTICUS; CENTRAL NERVOUS-SYSTEM; OPIATE RECEPTOR; BINDING-SITES; RAT PITUITARY; VASOPRESSIN; KAPPA; PLASMA; BRAIN; DYNORPHIN;
Keywords:
arginine vasotocin; chicks; hypertonic stimulation; angiotensin II; opioid receptor; naloxonazine; nor-BNI; naltrindole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, T Nagoya Univ, Grad Sch Bioagr Sci, Physiol Anim Lab, Nagoya, Aichi 4648601,Japan Nagoya Univ Nagoya Aichi Japan 4648601 oya, Aichi 4648601,Japan
Citazione:
T. Sasaki et al., "The effects of highly selective opioid receptor antagonists on the releaseof arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection", GEN C ENDOC, 118(3), 2000, pp. 365-372

Abstract

The effects of highly selective antagonists to mu- delta-, and kappa-opioid receptor subtypes on hyperosmotic- or angiotensin II (AII)-induced arginine vasotocin (AVT) release were investigated in chicks. Plasma levels of AVT increased about 1.5-fold after the administration of 1.5 M NaCl (200 mu l, ip) or 100 ng AII (5 mu l, icv). The administration of the mu-antagonist naloxonazine and the kappa-antagonist nor-Binaltorphimine further elevated plasma levels of AVT stimulated by hypertonic NaCl or AII. These effects ofmu- and kappa-opioid receptor antagonists on AVT release were dose dependent. Nor-Binaltorphimine enhanced hyperosmotically stimulated plasma levels of AVT at a lower dose than that of naloxonazine. Conversely, the delta-selective antagonist naltrindole did not significantly affect AVT secretion. None of the opioid receptor antagonists influenced basal plasma levels of AVT. Therefore, these results suggest that mu- and kappa-opioid receptors areinvolved in hyperosmotic- and AII-induced AVT release, and the effect of the kappa-opioid receptor antagonist in the AVT release stimulated by hyperosmolality is strong compared to that of the mu-opioid receptor antagonist. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:34:48