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Titolo:
Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice
Autore:
Vani, ML; Reddy, KP;
Indirizzi:
Osmania Univ, Dept Zool, Neurobiol Lab, Hyderabad 500007, Andhra Pradesh, India Osmania Univ Hyderabad Andhra Pradesh India 500007 Andhra Pradesh, India
Titolo Testata:
FLUORIDE
fascicolo: 1, volume: 33, anno: 2000,
pagine: 17 - 26
SICI:
0015-4725(200002)33:1<17:EOFAOS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; SODIUM-FLUORIDE; TOXICITY; PROTEIN; ATPASE; RATS; FLUOROSIS; CALCIUM; KIDNEY; RABBIT;
Keywords:
brain fluoride; enzyme activities; female mice; fluoride accumulation; fluoride; toxicity; gastrocnemius muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Reddy, KP Osmania Univ, Dept Zool, Neurobiol Lab, Hyderabad 500007, AndhraPradesh, India Osmania Univ Hyderabad Andhra Pradesh India 500007 adesh, India
Citazione:
M.L. Vani e K.P. Reddy, "Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice", FLUORIDE, 33(1), 2000, pp. 17-26

Abstract

This study reports accumulation of fluoride and altered activities of someenzymes involved in free-radical metabolism and membrane function in wholebrain and gastrocnemius muscle of female mice treated with NaF (20 mg/kg/body weight) for 14 days, The body weight and somatic index were decreased, whereas fluoride levels were significantly increased (p<0.01) in both brainand gastrocnemius muscle. The enzymes SOD, GST, and catalase decreased significantly (p<0.01) in contrast to XOD activity, which moderately increased. SDH, LDH, AlAT, AAT, and CPK activities and membrane-bound enzymes, viz Na+-K+, Mg++ and Ca(++)ATPase and AChE were decreased significantly (p<0.01)in both brain and gastrocnemius muscle. The effect of fluoride on enzymes of muscle was comparatively larger, which corroborates the greater accumulation of fluoride in muscle than brain. This study therefore shows that bothbrain and muscle are affected by fluoride with inhibition of some enzymes associated with free-radical metabolism, energy production and transfer, membrane transport, and synaptic transmission, but with an enhanced activity of XOD.

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Documento generato il 03/04/20 alle ore 20:35:47