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Titolo:
Characterisation of oxidative phosphorylation in skeletal muscle mitochondria subpopulations in pig: a study using top-down elasticity analysis
Autore:
Lombardi, A; Damon, M; Vincent, A; Goglia, F; Herpin, P;
Indirizzi:
Univ Sannio, Fac Sci, I-82100 Benevento, Italy Univ Sannio Benevento Italy I-82100 o, Fac Sci, I-82100 Benevento, Italy Univ Naples Federico II, Dipartimento Fisiol Gen & Ambientale, I-80134 Naples, Italy Univ Naples Federico II Naples Italy I-80134 tale, I-80134 Naples, Italy INRA, Unite Mixte Rech Veau & Porc, F-35590 St Gilles, France INRA St Gilles France F-35590 ech Veau & Porc, F-35590 St Gilles, France
Titolo Testata:
FEBS LETTERS
fascicolo: 2, volume: 475, anno: 2000,
pagine: 84 - 88
SICI:
0014-5793(20000616)475:2<84:COOPIS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLD-ACCLIMATED PIGLETS; SUBSARCOLEMMAL MITOCHONDRIA; RESPIRATION; METABOLISM; PROTEIN; OXYGEN;
Keywords:
skeletal muscle mitochondrion; top-down elasticity analysis; oxidative phosphorylation; respiratory chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Goglia, F Univ Sannio, Fac Sci, Via Port Arsa, I-82100 Benevento, Italy Univ Sannio Via Port Arsa Benevento Italy I-82100 evento, Italy
Citazione:
A. Lombardi et al., "Characterisation of oxidative phosphorylation in skeletal muscle mitochondria subpopulations in pig: a study using top-down elasticity analysis", FEBS LETTER, 475(2), 2000, pp. 84-88

Abstract

In skeletal muscle, two mitochondrial populations are present which, on the basis of their localisation, are termed intermyofibrillar and subsarcolemmal mitochondria (IMF and SS, respectively). These two populations have different biochemical characteristics and show different responses to physiological stimuli, In this paper, we characterise the oxidative phosphorylationof SS and IMF using 'top-down' elasticity analysis, We excluded the possibility that their different characteristics can be attributed to a differentdegree of breakage of the two types of mitochondria due to the different isolation procedures used in their preparation. The higher respiration rate and higher respiratory control ratio shown by IMF compared with those shownby SS are principally due to the higher activities of the reactions involved in substrate oxidation as confirmed by the measurement of cytochrome oxidase activity. There is no difference in the leak of protons across the inner mitochondrial membrane between IMF and SS; a faster rate of ATP synthesis and turnover is driven by the lower membrane potential in SS compared,vith in IMF. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:12:56