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Titolo:
Immunohistochemical localization of substance P and substance P receptor (NK1) in the olivary pretectal nucleus of the rat
Autore:
Klooster, J; Kamphuis, W; Vrensen, GFJM;
Indirizzi:
Netherlands Ophthalm Res Inst, Dept Morphol, NL-1105 BA Amsterdam, Netherlands Netherlands Ophthalm Res Inst Amsterdam Netherlands NL-1105 BA therlands
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 131, anno: 2000,
pagine: 57 - 63
SICI:
0014-4819(200003)131:1<57:ILOSPA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUPILLARY LIGHT REFLEX; LATERAL GENICULATE-NUCLEUS; EDINGER-WESTPHAL NUCLEUS; ALBINO-RAT; SUPERIOR COLLICULUS; SYNAPTIC TERMINALS; NEURONS; CAT; LUMINANCE; GLUTAMATE;
Keywords:
pupillary light reflex; olivary pretectal nucleus; substance P; NK1 receptor; ultrastructure; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Klooster, J Netherlands Ophthalm Res Inst, Dept Morphol, Meibergdreef 47, NL-1105 BA Amsterdam, Netherlands Netherlands Ophthalm Res Inst Meibergdreef 47 Amsterdam Netherlands NL-1105 BA
Citazione:
J. Klooster et al., "Immunohistochemical localization of substance P and substance P receptor (NK1) in the olivary pretectal nucleus of the rat", EXP BRAIN R, 131(1), 2000, pp. 57-63

Abstract

The olivary pretectal nucleus (OPN) is the first central nucleus in the pupillary light reflex are (PLR). Substance P (SP) is a neuropeptide present in the OPN, The present immunohistochemical study, performed at the ultrastructural level, aimed to determine the synaptic localization of SP and SP receptor in the OPN. Three types of SP-positive terminals were found. The most abundant type was of retinal origin, characterized by electron-lucent mitochondria and round vesicles, organized in glomerular structures, making asymmetric synaptic contacts with dendrites, and profiles containing pleomorphic vesicles, also making synaptic contacts with dendrites. The second type of SP-immunoreactive terminal contained electron-dense mitochondria and pleomorphic vesicles. This type made symmetric synaptic contacts and may originate from the ventral part of the lateral geniculate nucleus. The third type of SP-irnmunoreactive terminals contained electron-dense mitochondria, clear round vesicles, and made an asymmetric synaptic contact. This type originates from the contralateral OPN. SP receptors of the NK1 subtype were revealed to be on dendrites and were part of the glomerular-like arrangement. On account of the present observations, it can be concluded that retinal projections to the OPN use SP as a neurmodulator and synapse on NK1 receptor-containing dendrites of large neurons projecting to the Edinger-Westphal nucleus. Since SP also modulates the parasympathetic component of the PLR, we postulate that SP plays a modulating role in all components of the PLR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:11:02