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Titolo:
Reorganization of vibrissal motor representation following severing and repair of the facial nerve in adult rats
Autore:
Franchi, G;
Indirizzi:
Univ Ferrara, Dipartimento Sci Biomed & Terapie Avanzate, Sez Fisiol Umana, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 Fisiol Umana, I-44100 Ferrara, Italy
Titolo Testata:
EXPERIMENTAL BRAIN RESEARCH
fascicolo: 1, volume: 131, anno: 2000,
pagine: 33 - 43
SICI:
0014-4819(200003)131:1<33:ROVMRF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER-LIMB AMPUTATION; PERIPHERAL-NERVE; MOVEMENT REPRESENTATIONS; DYNAMIC ORGANIZATION; SOMATOSENSORY CORTEX; CORTICAL REPRESENTATION; HORIZONTAL CONNECTIONS; MAGNETIC STIMULATION; AFFERENT-PROJECTIONS; SUPERIOR COLLICULUS;
Keywords:
motor cortex; motor reinnervation; neural plasticity; facial motor control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Franchi, G Univ Ferrara, Dipartimento Sci Biomed & Terapie Avanzate, Sez Fisiol Umana, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 na, I-44100 Ferrara, Italy
Citazione:
G. Franchi, "Reorganization of vibrissal motor representation following severing and repair of the facial nerve in adult rats", EXP BRAIN R, 131(1), 2000, pp. 33-43

Abstract

This study examined the ability of adult rat motor cortex to reorganize its relationship with the somatic musculature following the severing and regeneration of a motor nerve. For this pul pose experiments were performed on ten male albino rats where the facial nerve on one side was severed, sutured and allowed to regenerate for 6 months. Cortical motor output organization was assessed by mapping the vibrissal movement area extension and thresholds: evoked by intracortical electrical stimulation in anesthetized rats. In all ten animals, the cortical output pattern of the motor cortex contralateral to the normal side was compared with that contralateral to the reinnervated side. After facial nerve reinnervation, the most notable differencesin primary motor cortex (M1) output organization in the hemispheres contralateral to the reinnervated side were: (a) the area from which vibrissa movements could he evoked at low thresholds was smaller (mean 1.2+/-0.38 mm, range 0.75-1.75 mm), decreasing to 64.2% below those in hemispheres contralateral to the normal side (mean 3.4+/-0.52 mm, range 2.5-4 mm). The reorganized vibrissa area consisted of contiguous or discontinuous points shrunken to the medialmost portion of normal M1 vibrissal representation. (b) There was a clear medial extension of the forelimb representation, and a more modest lateral expansion of eye representation, into the vibrissa territory. The mean threshold required to evoke vibrissa movements was significantly higher in the hemispheres contralateral to the reinnervated side than ill theother hemispheres (normal 23.9+/-9.7 mu A vs reinnervated 37.8+/-11.9 mu A: P less than or equal to 0.0001; t-test). The stimulation currents required to evoke other types of body movements were similar in the normal and reinnervated sides. Similar results were observed in all rats. In conclusion, these results indicate that motor nerve reinnervation is sufficient to produce long-lasting changes at a higher motor cortical level. This supports the notion that central supranuclear mechanisms may also be involved in the disorder of facial movements observed after facial nerve reinnervation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:04:36