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Titolo:
Effect of lung volume on the oesophageal diaphragm EMG assessed by magnetic phrenic nerve stimulation
Autore:
Luo, YM; Lyall, RA; Harris, ML; Hawkins, P; Hart, N; Polkey, MI; Moxham, J;
Indirizzi:
Univ London Kings Coll Hosp, Guys Kings & St Thomas Sch Med, Dept Resp Med& Allergy, Resp Muscle Lab, London SE5 9PJ, England Univ London Kings Coll Hosp London England SE5 9PJ ndon SE5 9PJ, England
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 6, volume: 15, anno: 2000,
pagine: 1033 - 1038
SICI:
0903-1936(200006)15:6<1033:EOLVOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRODE POSITION; ELECTROMYOGRAM; QUANTIFICATION; HUMANS;
Keywords:
diaphragm compound muscle; action potential; lung volume; magnetic stimulation; phrenic nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Luo, YM Univ London Kings Coll Hosp, Guys Kings & St Thomas Sch Med, Dept Resp Med& Allergy, Resp Muscle Lab, Bessemer Rd, London SE5 9PJ, England Univ London Kings Coll Hosp Bessemer Rd London England SE5 9PJ nd
Citazione:
Y.M. Luo et al., "Effect of lung volume on the oesophageal diaphragm EMG assessed by magnetic phrenic nerve stimulation", EUR RESP J, 15(6), 2000, pp. 1033-1038

Abstract

Previous studies have shown conflicting results on the effect of lung volume on the diaphragm compound muscle action potential (CMAP). Consequently, the ability to quantify the oesophageal diaphragm electromyography (EMG) has been questioned. If lung volume changes have little effect on the diaphragm CMAP the accurate measurement of voluntary EMC, as an index of respiratory drive, may be possible. Furthermore, the measurement of CMAP could provide useful clinical information when evaluating patients with neuromuscular disease. To reassess the effect of lung volume on the oesophageal diaphragm CMAP, six normal subjects were studied using an oesophageal catheter incorporatingseven electrodes (number one being proximal and seven distal) that were 1 cm in length and 1 cm apart. Electrode number three was positioned at the centre of the electrically active region of the diaphragm (EARdi) at functional residual capacity (FRC), The diaphragm CMAP elicited by bilateral magnetic stimulation of the phrenic nerves was simultaneously recorded from fourelectrode pairs. Pair one was created from electrodes one and three, pair two from electrodes two and four, pair three from electrodes three and five, and pair four from electrodes five and seven. Phrenic nerve stimulation was at residual volume (RV), FRC, FRC+1.0 L, FRC+2.0 L, and total lung capacity (TLC). The CMAP recorded from pair one was least influenced by changes in lung volume and the amplitude was 2.41+/-0.39 (mean+/-SD), 2.60+/-0.27, 2.64+/-0.29, and 2.71+/-0.45 mV at RV, FRC, FRC+1.0 L and FRC+2.0 L, respectively. AtTLC the CMAP was more variable. The CMAP amplitude recorded from pair two increased with increasing long volume and at FRC+2.0 L was 3.7 times largerthan that at FRC, Pair four usually recorded substantially smaller CMAPs at all lung volumes. This study shows that the diaphragm compound muscle action potential recorded from an oesophageal electrode just above the diaphragm is relatively stable over the lung volume range residual volume to functional residual capacity+2.0 L.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 04:26:13