Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Changes in catecholaminergic pathways innervating the rat heart ventricle during morphine dependence. Involvement of alpha(1)- and alpha(2)-adrenoceptors
Autore:
Milanes, MV; Laorden, ML;
Indirizzi:
Univ Murcia, Sch Med, Dept Physiol & Pharmacol, Pharmacol Unit, Murcia, Spain Univ Murcia Murcia Spain iol & Pharmacol, Pharmacol Unit, Murcia, Spain
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 397, anno: 2000,
pagine: 311 - 318
SICI:
0014-2999(20000602)397:2-3<311:CICPIT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALOXONE-PRECIPITATED WITHDRAWAL; GUINEA-PIG HEART; NORADRENERGIC NEURONS; OPIOID-PEPTIDES; EXPRESSION; CLONIDINE; BRAIN; YOHIMBINE; ALPHA-2-ADRENOCEPTORS; PHARMACOLOGY;
Keywords:
morphine withdrawal; ventricle, right; catecholaminergic activity; yohimbine; prazosin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Laorden, ML Fac Med, Dept Farmacol, Campus Espinardo, Murcia 301000, SpainFac Med Campus Espinardo Murcia Spain 301000 ia 301000, Spain
Citazione:
M.V. Milanes e M.L. Laorden, "Changes in catecholaminergic pathways innervating the rat heart ventricle during morphine dependence. Involvement of alpha(1)- and alpha(2)-adrenoceptors", EUR J PHARM, 397(2-3), 2000, pp. 311-318

Abstract

In the present study, we examined the effects of alpha(1)- and the alpha(2)-adrenoceptors blockade on the changes in the ventricular content of catecholamines in rats withdrawn from morphine. Rats were given morphine by s.c.implantation of morphine pellets for 5 days. On the seventh day, morphine withdrawal was induced by s.c. administration of naloxone (1 mg/kg), and rats were killed 30 min later. Pretreatment with yohimbine (alpha(2)-adrenoceptor) or prazosin (alpha(1)-adrenoceptor) 15 min prior to naloxone administration attenuated some of the behavioural signs of morphine withdrawal. In addition, biochemical analysis indicated that yohimbine completely abolished the withdrawal-induced increase in noradrenaline acid dopamine turnover in the right ventricle. By contrast, prazosin did not block the hyperactivity of catecholaminergic neurons in the heart during withdrawal. These data suggest that the hyperactivity of catecholaminergic neurons in the heart during morphine withdrawal is dependent upon alpha(2)-adrenoceptor activation. In addition, the present results rule out the involvement of alpha(1)-adrenoceptors. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:27:15