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Titolo:
Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration
Autore:
Burrows, KB; Gudelsky, G; Yamamoto, BK;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Psychiat, Program Basic & Clin Neurosci, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA44106 Cleveland, OH 44106 USA Univ Cincinnati, Coll Pharm, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 l Pharm, Cincinnati, OH 45267 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 398, anno: 2000,
pagine: 11 - 18
SICI:
0014-2999(20000609)398:1<11:RATIOM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; CYTOCHROME-OXIDASE; NITRIC-OXIDE; INDUCED NEUROTOXICITY; MDMA ECSTASY; RAT-BRAIN; DOPAMINE; SEROTONIN; STRIATUM; ATP;
Keywords:
neurotoxicity; cytochrome oxidase; amphetamine; histochemistry; energy metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, BK Univ Hosp Cleveland, Dept Psychiat, Program Basic & Clin Neurosci, Hanna Pavil Room B68,11100 Euclid Ave, Cleveland, OH 44106 USA Univ Hosp Cleveland Hanna Pavil Room B68,11100 Euclid Ave Cleveland OH USA 44106
Citazione:
K.B. Burrows et al., "Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration", EUR J PHARM, 398(1), 2000, pp. 11-18

Abstract

Metabolic mapping of discrete brain regions using cytochrome oxidase histochemistry was used as a marker For alterations in mitochondrial function and cytochrome oxidase enzymatic activity in response to high doses of amphetamine derivatives. The activity of cytochrome oxidase, complex IV of the electron transport chain, was determined at three different time-points following administration of high doses of methamphetamine or 3,3-methylenedioxymethamphetamine (MDMA) (four injections of 10-15 mg/kg administered over 8 h). There was a rapid decrease in cytochrome oxidase staining in the striatum (23-29%), nucleus accumbens (29-30%) and substantia nigra (31-43%), 2 h following administration of either methamphetamine and MDMA. This decrease in cytochrome oxidase activity was transient and returned to control levels within 24 h. Since the methamphetamine and MDMA-induced decrease in cytochrome oxidase activity was localized to dopamine-rich regions, increased extracellular concentrations of dopamine may contribute to the inhibition of metabolic function via its metabolism to form quinones or other reactive oxygen species. These results support previous studies demonstrating that psychostimulants induce a rapid and transient decrease in striatal ATP stores and provide further evidence that these drugs of abuse can disrupt mitochondrial function. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 07:20:31