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Titolo:
Effects of carbamazepine on acetylcholine release and metabolism
Autore:
Mizuno, K; Okada, M; Murakami, T; Kamata, A; Zhu, G; Kawata, Y; Wada, K; Kaneko, S;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2-3, volume: 40, anno: 2000,
pagine: 187 - 195
SICI:
0920-1211(200007)40:2-3<187:EOCOAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE EPILEPSY; ADENOSINE RECEPTOR SUBTYPES; POTASSIUM CHANNEL GENE; IN-VIVO MICRODIALYSIS; DOPAMINERGIC SYSTEM; SEROTONERGIC SYSTEM; STRIATAL DOPAMINE; MUTATION; ZONISAMIDE; FAMILY;
Keywords:
acetylcholine; carbamazepine; epilepsy; hippocampus; microdialysis; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, M Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 omori 0368562, Japan
Citazione:
K. Mizuno et al., "Effects of carbamazepine on acetylcholine release and metabolism", EPILEPSY R, 40(2-3), 2000, pp. 187-195

Abstract

To clarify the mechanisms of action of carbamazepine (CBZ), we investigated the effects of CBZ on acetylcholine (ACh) release and metabolism in rat striatum and hippocampus. Acute administration of effective dose of CBZ (25 mg/kg) increased both striatal and hippocampal extracellular levels of ACh,whereas a supraeffective dose of CBZ (50 mg/kg) did not affect the levels and a toxic dose of CBZ (100 mg/kg) decreased the extracellular ACh levels in both brain legions. Both acute and chronic administrations of CBZ (25 and 50 mg/kg, mg/kg per day) increased intracellular ACh levels in striatum and hippocampus. The striatal intracellular ACh levels were decreased by both acute and chronic administrations of CBZ (100 mg/kg, mg/kg per day), whereas the hippocampal intracellular ACh levels were not affected. The effective CBZ concentration did not affect cholinesterase activity, whereas supraeffective CBZ concentration reduced it weakly. Effective dose of CBZ enhanced ACh release and synthesis; however, supraeffective doses of CBZ reduced ACh release and synthesis without enhancement of ACh degradation, indicatingthat CBZ has biphasic effects on ACh release and synthesis. Thus, the present findings, the slight stimulation of ACh function by effective dose of CBZ, are involved, at least partially, in the antiepileptic and mood stabilizing mechanisms of action of CBZ. (C) 2000 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:39:34