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Titolo:
A tiered approach for assessing children's exposure
Autore:
Armstrong, TW; Hushka, LJ; Tell, JG; Zaleski, RT;
Indirizzi:
Exxon Biomed Sci Inc, Annandale, NJ 08801 USA Exxon Biomed Sci Inc Annandale NJ USA 08801 Inc, Annandale, NJ 08801 USA
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
fascicolo: 6, volume: 108, anno: 2000,
pagine: 469 - 474
SICI:
0091-6765(200006)108:6<469:ATAFAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEE ET-AL; BODY-WEIGHT; HISTORICAL MISINTERPRETATION; LOGNORMAL DISTRIBUTIONS; INHALATION EXPOSURE; HUMAN-POPULATIONS; DERMAL EXPOSURE; SOIL ADHERENCE; FOOD-INTAKE; SKIN;
Keywords:
assessment; chemical; children; exposure; exposure factors; health; margin of exposure; tiered;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Armstrong, TW Exxon Biomed Sci Inc, POB 971,1545 Route 22 E, Annandale, NJ08801 USA Exxon Biomed Sci Inc POB 971,1545 Route 22 E Annandale NJ USA 08801
Citazione:
T.W. Armstrong et al., "A tiered approach for assessing children's exposure", ENVIR H PER, 108(6), 2000, pp. 469-474

Abstract

Recently, intense attention has been given to children's health issues, particularly in che use of consumer products. Because of this attention, researchers have been planning and initiating studies specifically aimed at developing both toxicology data and exposure data directed to improve our understanding of industrial and consumer product chemical impacts on children'shealth. To ensure that this research is focused on the highest priority chemicals, we present a methodology for determining and prioritizing the higher ha Lard chemicals and scenarios for which children could be disproportionately or highly exposed. This tiered approach includes a screening step for initial chemical selection, a hazard assessment based on no- or Lowest-observed-adverse-effect levels, and a margin of exposure (MOE) calculation. The initial chemical screen focuses on the chemical presence in specific media that are special to children, such as foods children regularly ear and drink, residential or school air, products children use, and soil and dust in and around residences. Data from the literature or from models serve as the initial exposure estimate. This methodology would allow us to focus on those chemicals to which children are most exposed that are also associated with, potentially, the highest risk. rise of the MOE calculation allows forcomparison among chemicals, prioritization of chemicals for evaluation andtesting, and identification of significant data gaps.

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Documento generato il 31/10/20 alle ore 00:11:36