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Titolo:
Effects of growth hormone-releasing hormone-related peptide on stem cell factor expression in cultured rat Sertoli cells
Autore:
Steinmetz, R; Lazzaro, N; Rothrock, JK; Pescovitz, OH;
Indirizzi:
Indiana Univ, Sch Med, Dept Pediat, Wells Ctr Pediat Res,Sect Pediat Endocrinol & Dia, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 & Dia, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Physiol & Biophys, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 iophys, Indianapolis, IN 46202 USA
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 12, anno: 2000,
pagine: 323 - 327
SICI:
1355-008X(200006)12:3<323:EOGHHP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; MESSENGER-RIBONUCLEIC-ACID; TESTIS; GENE; LEUKOCYTES; RNA; PRECURSOR; SEQUENCE; MOUSE;
Keywords:
growth hormone-releasing hormone-related peptide; Sertoli cells; stem cell factor; protein kinase A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Steinmetz, R James Whitcomb Riley Hosp Children, Rm 2627,702 Barnhill Dr, Indianapolis,IN 46202 USA James Whitcomb Riley Hosp Children Rm 2627,702 Barnhill Dr Indianapolis IN USA 46202
Citazione:
R. Steinmetz et al., "Effects of growth hormone-releasing hormone-related peptide on stem cell factor expression in cultured rat Sertoli cells", ENDOCRINE, 12(3), 2000, pp. 323-327

Abstract

The growth hormone-releasing hormone(GHRH) gene produces a precursor molecule that contains GHRH and a carboxyl-terminal peptide that we have named GHRH-related peptide (GHRH-RP). This peptide, like GHRH, stimulates the expression of stem cell factor (SCF), an important reproductive and hematopoietic cytokine, in vitro and in vivo. In the present study, using primary cultures of rat Sertoli cells, we compared the time course of action and the level of SCF stimulation seen following treatment with GHRH-RP and GHRH. Additionally, we investigated the activity of a truncated peptide, p75-92NH2, whose sequence is contained within GHRH-RP, All three of these peptides wereshown to stimulate the steady-state levels of SCF mRNA to a comparable degree. However, the time course of action for GHRH-RP differed markedly from that of GHRH. GHRH-RP and p75-92NH2, similar to GHRH, induce SCF expression, at least in part, via the activation of the protein ki nase A/cyclic adenosine monophosphate intracellular signaling pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:58:09