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Titolo:
Effects of immobilization stress on estrogen-induced surges of luteinizinghormone and prolactin in ovariectomized rats
Autore:
Kam, K; Park, Y; Cheon, M; Son, GH; Kim, K; Ryu, K;
Indirizzi:
Yonsei Univ, Coll Med, Dept Pharmacol, Seoul 120752, South Korea Yonsei Univ Seoul South Korea 120752 harmacol, Seoul 120752, South Korea Yonsei Univ, Coll Med, Endocrine Lab, Seoul 120752, South Korea Yonsei Univ Seoul South Korea 120752 rine Lab, Seoul 120752, South Korea Seoul Natl Univ, Coll Nat Sci, Dept Biol Mol, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 Mol, Seoul 151742, South Korea Seoul Natl Univ, Coll Nat Sci, Res Ctr Cell Differentiat, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 tiat, Seoul 151742, South Korea
Titolo Testata:
ENDOCRINE
fascicolo: 3, volume: 12, anno: 2000,
pagine: 279 - 287
SICI:
1355-008X(200006)12:3<279:EOISOE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-RELEASING-HORMONE; RECEPTOR MESSENGER-RNA; FEMALE RATS; GLUCOCORTICOID RECEPTOR; RESTRAINT STRESS; GENE-EXPRESSION; ARGININE-VASOPRESSIN; PITUITARY RECEPTORS; ENDOGENOUS OPIOIDS; PLASMA PROLACTIN;
Keywords:
immobilization stress; luteinizing hormone; prolactin; gonadotropin-releasing hormone; gonadotropin-releasing hormone receptor; dopamine D2 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Ryu, K Yonsei Univ, Coll Med, Dept Pharmacol, Seoul 120752, South Korea Yonsei Univ Seoul South Korea 120752 l, Seoul 120752, South Korea
Citazione:
K. Kam et al., "Effects of immobilization stress on estrogen-induced surges of luteinizinghormone and prolactin in ovariectomized rats", ENDOCRINE, 12(3), 2000, pp. 279-287

Abstract

Reproductive Function has been known to be impaired by various kinds of physical and emotional stress, but the mechanism by which stress impairs the reproductive axis has not been clearly understood. In the present study, the effects of immobilization stress were studied on the surges of luteinizing hormone (LH) and prolactin (PRL) induced by 17 beta-estradiol (E-2) in ovariectomized rats. Two weeks after bilateral ovariectomy, animals were implanted with the capsule containing E-2 or vehicle at 1000 h (designated as d0), Immobilization was started at 1000 h and continued to 2100 h on d 2. Blood samples were collected according to the time schedule by a jugular vein catheter procedure. Immobilization stress inhibited basal release of LH and abolished E-2-induced LH and PRL surges in ovariectomized (OVX) rats. Daily repeated immobilization (from 1200 h to 1800 h, 6 h/d) for 3 d also abolished LH and PRL surges when examined at 1800 h on d 2, Although daily repeated immobilization stress reduced E-2-induced PRL mRNA levels, this stress failed to change LH beta mRNA levels in the anterior pituitary as determined by Northern blot analysis. Gonadotropin-releasing hormone (GnRH) receptor mRNA levels in the anterior pituitary were lowered by immobilization stress in the OVX, E-2-treated group. Dopamine D2 receptor mRNA levels in the anterior pituitary of OVX, E-2-treated rats were significantly decreased at1800 h, compared with those at 1000 h, However, immobilization prevented adecrease in dopamine D2 receptor mRNA levels at 1800 h. GnRH content was increased in the mediobasal hypothalamus by immobilization in the OVX, E-2-treated group, suggesting that GnRH release was inhibited, Interestingly, GnRH mRNA levels in the preoptic area-anterior hypothalamic area were suppressed by immobilization stress in OVX, E-2-treated rats when determined at 1800 h. Therefore, we concluded that immobilization stress blocks E-2-inducedLH surge possibly by inhibiting synthesis and release of GnRH at the hypothalamic level, and an increase of dopaminergic activity via D2 receptor at the pituitary level might be involved in the stress blockage of E-2-inducedPRL surge.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:53:47