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Titolo:
Biogenic amine transporters: regulation in flux
Autore:
Blakely, RD; Bauman, AL;
Indirizzi:
Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Ctr Mol Neurosci, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Neurosci, Nashville, TN 37232 USA
Titolo Testata:
CURRENT OPINION IN NEUROBIOLOGY
fascicolo: 3, volume: 10, anno: 2000,
pagine: 328 - 336
SICI:
0959-4388(200006)10:3<328:BATRIF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN DOPAMINE TRANSPORTER; HUMAN NOREPINEPHRINE TRANSPORTER; SENSITIVE SEROTONIN TRANSPORTER; SINGLE-NUCLEOTIDE POLYMORPHISMS; HUMAN NORADRENALINE TRANSPORTER; BRAIN GABA TRANSPORTER; FUNCTIONAL REGULATION; SURFACE EXPRESSION; XENOPUS-OOCYTES; DEFICIENT MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Blakely, RD Vanderbilt Univ, Sch Med, Dept Pharmacol, 221 Kirkland Hall, Nashville, TN37232 USA Vanderbilt Univ 221 Kirkland Hall Nashville TN USA 37232 2 USA
Citazione:
R.D. Blakely e A.L. Bauman, "Biogenic amine transporters: regulation in flux", CUR OP NEUR, 10(3), 2000, pp. 328-336

Abstract

Following vesicular release, the biogenic amine neurotransmitters dopamine, norepinephrine and serotonin are actively cleared from extracellular spaces by presynaptic transporters. These transporters interact with multiple psychoactive agents including cocaine, amphetamines and antidepressants. Recent findings indicate that amine reuptake is likely to be a tightly regulated component of synaptic plasticity rather than a constitutive determinant of transmitter clearance. Protein kinase C activation and transporter phosphorylation have been linked to regulatory protein trafficking, and both phosphorylation and trafficking may be influenced by transporter ligands. Recognition that transmitters, antagonists and second messengers can modify theintrinsic activity, surface expression or protein levels of amine transporters raises new questions about the fundamental nature of drug actions in vivo. The theory that dysregulation of transporters may contribute to disease states is supported by the recent discovery that a coding mutation in thehuman norepinephrine transporter contributes to orthostatic intolerance.

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Documento generato il 28/03/20 alle ore 22:08:48