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Titolo:
Effect of lung water content, manipulated by intratracheal furosemide, surfactant, or a mixture of both, on compliance and viscoelastic tissue forcesin lung-lavaged newborn piglets
Autore:
Flemmer, A; Simbruner, G; Muenzer, S; Proquitte, H; Haberl, C; Nicolai, T; Leiderer, R;
Indirizzi:
Univ Munich, Dr Von Haunerschen Kinderspital, Univ Childrens Hosp, D-80337Munich, Germany Univ Munich Munich Germany D-80337 hildrens Hosp, D-80337Munich, Germany Univ Munich, Klinikum Grosshadern, Inst Surg Res, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 Inst Surg Res, D-8000 Munich, Germany
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 6, volume: 28, anno: 2000,
pagine: 1911 - 1917
SICI:
0090-3493(200006)28:6<1911:EOLWCM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; BRONCHOPULMONARY DYSPLASIA; EXOGENOUS SURFACTANT; PRETERM INFANTS; INHALED FUROSEMIDE; PULMONARY-FUNCTION; PREMATURE-INFANTS; CARE PRACTICES; THERAPY;
Keywords:
furosemide; topical; intratracheal; administration; respiratory distress syndrome; lung mechanics; stress adaptation; surfactant; lung water; animal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Simbruner, G Univ Munich, Dr Von Haunerschen Kinderspital, Univ Childrens Hosp, Lindwurmstr 4, D-80337 Munich, Germany Univ Munich Lindwurmstr 4 Munich Germany D-80337 ch, Germany
Citazione:
A. Flemmer et al., "Effect of lung water content, manipulated by intratracheal furosemide, surfactant, or a mixture of both, on compliance and viscoelastic tissue forcesin lung-lavaged newborn piglets", CRIT CARE M, 28(6), 2000, pp. 1911-1917

Abstract

Objective:To study the impact of lung water content and its reduction by atopically applied diuretic on respiratory and lung tissue mechanics in comparison with surfactant administration in surfactant-deficient newborn piglets with lavage-induced lung injury,Design: Controlled, randomized study. Setting: Animal research facility. Subjects: Newborn piglets. Treatment Piglets were surfactant depleted by lung lavage and, after a pretreatment period, randomly treated with intratracheal furosemide, furosemide and surfactant, or with surfactant alone. Measurements and Main Results:Dynamic compliance (C-DYN), static compliance (Csr), stress-adaptation pressures (P-DIFF) and post mortem lung water content were determined. Static compliance in the furo-semidesurfactant groupwas not significantly higher than in the surfactant group. At the end of the study, CST did not differ between the three groups because Csr in the furosemide group had increased to values similar to those of the surfactant-containing treatment groups: Csr F+S 0.73 +/- 0.2 mL/cm H2O/kg body weight (BW); CST: 0.61 +/- 0.11 compliance was inversely and P-DIFF was directly correlated to lung water (LW) content (CST VS. LW: r(2) = .59, p = .001; CDYNvs. LW: r2 = .49, p = .006; PDIFF vs. LW: r2 = .37, p = .069), independentof the type of treatment Changes in Csr and C-DYN were inversely related to changes in P-DIFF. Intrapulmonary furosemide was more rapidly absorbed when administered to the surfactant-depleted lung alone compared with the mixture with surfactant, and intrapulmonary furosemide had a rapid systemic effectConclusion: Although the combination of surfactant with a diuretic failed to increase respiratory compliance to a significantly larger extent than surfactant atone, furosemide at the end of the study increased respiratory compliance to a level similar to surfactant-containing treatments. Lung watercontent and, to a lesser extent, the absence or presence of surfactant appeared to determine lung mechanics, and its impact on lung mechanics was similar to surfactant administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:50:29